PR14L_HUMAN
ID PR14L_HUMAN Reviewed; 2151 AA.
AC Q5THK1; Q5THK4; Q6ZNN1; Q6ZWH0; Q8IW74; Q9H5T4;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein PRR14L;
DE AltName: Full=Proline rich 14-like protein;
GN Name=PRR14L; Synonyms=C22orf30;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-2151 (ISOFORM 3), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1332-2151 (ISOFORM 2), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1945-2151 (ISOFORM 1).
RC TISSUE=Adrenal gland, Lung, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1699-2151 (ISOFORM 4).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1029, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-582; SER-945 AND SER-1029,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q5THK1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5THK1-2; Sequence=VSP_027048;
CC Name=3;
CC IsoId=Q5THK1-3; Sequence=VSP_027046, VSP_027047;
CC Name=4;
CC IsoId=Q5THK1-4; Sequence=VSP_027049;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH40859.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB15536.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB15536.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC85470.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC85533.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CT841517; CAJ86447.1; -; mRNA.
DR EMBL; AC005004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL031255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK026712; BAB15536.1; ALT_SEQ; mRNA.
DR EMBL; AK123082; BAC85533.1; ALT_INIT; mRNA.
DR EMBL; AK130944; BAC85470.1; ALT_INIT; mRNA.
DR EMBL; BC040859; AAH40859.1; ALT_INIT; mRNA.
DR CCDS; CCDS13900.2; -. [Q5THK1-1]
DR RefSeq; NP_775837.2; NM_173566.2. [Q5THK1-1]
DR RefSeq; XP_006724282.1; XM_006724219.3.
DR RefSeq; XP_006724283.1; XM_006724220.3.
DR RefSeq; XP_011528382.1; XM_011530080.2.
DR RefSeq; XP_011528383.1; XM_011530081.2.
DR RefSeq; XP_016884225.1; XM_017028736.1.
DR RefSeq; XP_016884226.1; XM_017028737.1.
DR AlphaFoldDB; Q5THK1; -.
DR BioGRID; 128956; 65.
DR IntAct; Q5THK1; 21.
DR STRING; 9606.ENSP00000331845; -.
DR iPTMnet; Q5THK1; -.
DR PhosphoSitePlus; Q5THK1; -.
DR SwissPalm; Q5THK1; -.
DR BioMuta; PRR14L; -.
DR DMDM; 74746580; -.
DR EPD; Q5THK1; -.
DR jPOST; Q5THK1; -.
DR MassIVE; Q5THK1; -.
DR MaxQB; Q5THK1; -.
DR PaxDb; Q5THK1; -.
DR PeptideAtlas; Q5THK1; -.
DR PRIDE; Q5THK1; -.
DR ProteomicsDB; 65153; -. [Q5THK1-1]
DR ProteomicsDB; 65154; -. [Q5THK1-2]
DR ProteomicsDB; 65155; -. [Q5THK1-3]
DR ProteomicsDB; 65156; -. [Q5THK1-4]
DR Antibodypedia; 45489; 25 antibodies from 12 providers.
DR DNASU; 253143; -.
DR Ensembl; ENST00000327423.11; ENSP00000331845.6; ENSG00000183530.14. [Q5THK1-1]
DR GeneID; 253143; -.
DR KEGG; hsa:253143; -.
DR MANE-Select; ENST00000327423.11; ENSP00000331845.6; NM_173566.3; NP_775837.2.
DR UCSC; uc003alp.5; human. [Q5THK1-1]
DR CTD; 253143; -.
DR DisGeNET; 253143; -.
DR GeneCards; PRR14L; -.
DR HGNC; HGNC:28738; PRR14L.
DR HPA; ENSG00000183530; Low tissue specificity.
DR neXtProt; NX_Q5THK1; -.
DR OpenTargets; ENSG00000183530; -.
DR PharmGKB; PA145149425; -.
DR VEuPathDB; HostDB:ENSG00000183530; -.
DR eggNOG; ENOG502RJ6E; Eukaryota.
DR GeneTree; ENSGT00520000055626; -.
DR HOGENOM; CLU_001409_0_0_1; -.
DR InParanoid; Q5THK1; -.
DR OMA; MSCHDES; -.
DR OrthoDB; 20650at2759; -.
DR PhylomeDB; Q5THK1; -.
DR TreeFam; TF328446; -.
DR PathwayCommons; Q5THK1; -.
DR SignaLink; Q5THK1; -.
DR BioGRID-ORCS; 253143; 21 hits in 1078 CRISPR screens.
DR ChiTaRS; PRR14L; human.
DR GenomeRNAi; 253143; -.
DR Pharos; Q5THK1; Tdark.
DR PRO; PR:Q5THK1; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q5THK1; protein.
DR Bgee; ENSG00000183530; Expressed in gingival epithelium and 179 other tissues.
DR ExpressionAtlas; Q5THK1; baseline and differential.
DR Genevisible; Q5THK1; HS.
DR InterPro; IPR026320; PRR14.
DR InterPro; IPR028149; Tantalus-like.
DR PANTHER; PTHR14522; PTHR14522; 1.
DR Pfam; PF15386; Tantalus; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..2151
FT /note="Protein PRR14L"
FT /id="PRO_0000295739"
FT REGION 112..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1782..1802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1986..2012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1010
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 157
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17525332"
FT MOD_RES 582
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 945
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1029
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1234..1239
FT /note="SLKSIE -> SPCLTT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027046"
FT VAR_SEQ 1240..2151
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027047"
FT VAR_SEQ 2001..2151
FT /note="AEPEKRPKKVSQIRIRKTIPRPDPNLTPMGLPRPKRLKKKEFSLEEIYTNKN
FT YKSPPANRCLETIFEEPKERNGTLISISQQKRKRVLEFQDFTVPRKRRARGKVKVAGSF
FT TRAQKAAVQSRELDALLIQKLMELETFFAKEEEQEQSSGC -> VKEEGV (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027048"
FT VAR_SEQ 2061..2151
FT /note="CLETIFEEPKERNGTLISISQQKRKRVLEFQDFTVPRKRRARGKVKVAGSFT
FT RAQKAAVQSRELDALLIQKLMELETFFAKEEEQEQSSGC -> DLDSSCPSTDSETGHF
FT LVFGYAQRQAQPHPLLASRRLIGCSSPEGRGHPRSYPYWRRLLVLCWYLPGWRAGRVTW
FT LRLATWAGRGDSSL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027049"
FT VARIANT 455
FT /note="N -> S (in dbSNP:rs140081)"
FT /id="VAR_059641"
FT VARIANT 740
FT /note="L -> P (in dbSNP:rs140080)"
FT /id="VAR_059642"
FT VARIANT 876
FT /note="M -> I (in dbSNP:rs17821493)"
FT /id="VAR_059643"
FT VARIANT 961
FT /note="T -> I (in dbSNP:rs140079)"
FT /id="VAR_059644"
FT VARIANT 963
FT /note="D -> N (in dbSNP:rs9619227)"
FT /id="VAR_059645"
FT VARIANT 1151
FT /note="S -> P (in dbSNP:rs12159328)"
FT /id="VAR_059646"
FT VARIANT 1221
FT /note="S -> L (in dbSNP:rs140078)"
FT /id="VAR_059647"
FT VARIANT 1316
FT /note="E -> K (in dbSNP:rs61461793)"
FT /id="VAR_061637"
FT VARIANT 1395
FT /note="L -> F (in dbSNP:rs3804090)"
FT /id="VAR_059648"
FT VARIANT 1784
FT /note="V -> I (in dbSNP:rs16989427)"
FT /id="VAR_059649"
FT CONFLICT 885
FT /note="I -> N (in Ref. 3; BAB15536)"
FT /evidence="ECO:0000305"
FT CONFLICT 1223
FT /note="S -> F (in Ref. 3; BAB15536)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2151 AA; 237300 MW; A1E0277094885E1F CRC64;
MLSSGVETQP VPLDSSMSAV VQELYSELPV SVSRELHADP EPSVIPDVKP GASSSLLSQN
RALPLELQRT HVESCCEETY ETLDHGSEPG RCGLVDSTAG GSVASGILDR AKRSESMEPK
VFRDPGGQAG IIREPSEGAK EDPHQHSTAA EEKTSPSQED LLMQSSKELS HVDLPEDFLR
SKEGNVQITA ETLLKSAEVQ GMKVNGTKTD NNEGHKNGNV SKDLSAGCGE FQEVDKIMTS
DEVSETSTLV TPEPLTFVDP VLTEATPKEK ECEELKSCPW LSLPGNSAIS NVDNGKEELC
KPNLVCEADD NHQQLHGHHN EQPSSTHDSP TATSPLKENS EVSCFTSDLS GPESRTISLE
NCGFEGGGLL KRSAEKTDSS YFYRGDDQGK NLASREENEE RLLIPRSERG GPFLFNAREP
EKEISGRCSG EKEPVVSPKE NIHNNCIQDS LHTGNSSSLM PNSFTEATEV MLNKNDLKIT
VHVQGNLTNP EDHKETFTNM SHPGGHSEES SFSSLMQIEE AGQTTPVEPN ILSKSFYTKD
CNSLVSIQRN LEGNTQLNEA SCNDFLFERK SIVSLMPEDQ ISPVSEVLKP KQGTALLLPS
PEFDYRPESE KVIQTSHDDI PLLDEQSIAC EMNELSCTNE LVVNKVESEC VLNQQVSLNS
QEHANLPTDS LLHLNKEMPL ATGRDAHQSH HPPLEGRADV IADIQTIPIQ TKIKDISPPG
NQTCGASSNC PTLNIKPVSL ERKKEMADSG TKALHSRLRS NKREAAGFPQ VVSVIECHSV
QSQDISSCHR VRKNVSQENM CSASAAFKSS KISLQVDNSL ITKYENAFQH RDHCCQGTGH
SVEKSSCKVS YTSQERELDG KETNGSLPGD KIRNKMVAGL LNSGISNKTI HTSSSIKLSE
EGLEGKEQDV SKETVFCKYN ISDHAIQELN QTVNIPGPEK VLDQSPTVMF SSFKNVKSVE
TLDQKADEVL DCQSNQNRPD ECKSEGQSAK EMLSSDQRET VTEPHGEVNH NQKDLLVSSG
SNNSLPCGSP KKCNLKGAFV KMSGCDESTE GMVDIVYTDC SNKLAEGVLD VKASNLLDCG
ARQEKLAFQE DSRSTLSRRE LDAAHTGTTG QDSDFPVTAA STVDFLKIKK SCEENVCRSL
KDCEMEKCPD SCAHEMESVA DHEPNKRILG RVNLSLNDSH YGQQDKGTSL RETQEMTEGS
RLEPNSEFGK ESTFGISSKE SMSCHDESSV SLRSLKSIEI MPSQENSETN VNSEETDLKN
LCKPKDGEML CENVKDCTVL PEMKEIVSRD WSNSSDRDSV CTCVEKNACK ACHPHENSSD
RHLPLTVKTD IKVKGEETEE HQRGRLGYLT VGEQSEELVT RETGDGDPVS NISQTHFKCR
GILNHAEKQQ SPEVLDYMLQ KEEKYIRQQK AHTISQQCIS SSLLLDDAQN QNQPKADKDE
STMINEITLA KLAKDSIVAQ TQKLEDQKEE RLHHPLRKDT ESCTSPCLLG APRKAQDPSS
AGCDQIHGAF AKKGVLPLKK QPHRTCKKVS YQEQIIVGRK IGKIRSSAFL KSSSNPIPTK
AHRLLSLCTL SAPTRLEPET APTKSLVSHI PKQMSTPCHP LRSLNFRKTT KESALLNKLS
ILASKLAPAM KTQKLRYRRC SSELLPMAKS YKRLRYKRLL DGFSSSTEQL NPYLAASGWD
KRPNSKPMAL YSLESIKMTF IDLSNKMPSL LFGSEIFPVS FHVKSSSSDC TTESSRTFPE
HCAPARLALG EALQCPSQPP KWTFSFFLSH GCPGMATFRE DTGVHSQTHT QAPPQPPAPL
QDYGGTAIVQ TRADCSVLGL HTLLALCSPG CYRIWTKKRS FSSHMPTMQR LFMTQFTQGL
KGLRSPASIA DKVFCSLPYS VGRVLSIWSQ HGPSVCSFEI SSLHSPHCKR QPSLGTTSSH
TMLPYVPLPG MEATYNTSGS QTRLEPPFPA LVPKSCLVAE SAVSKLLLSA SEFQVRGLDE
LDGVKAACPC PQSSPPEQKE AEPEKRPKKV SQIRIRKTIP RPDPNLTPMG LPRPKRLKKK
EFSLEEIYTN KNYKSPPANR CLETIFEEPK ERNGTLISIS QQKRKRVLEF QDFTVPRKRR
ARGKVKVAGS FTRAQKAAVQ SRELDALLIQ KLMELETFFA KEEEQEQSSG C
