PR1B2_ARATH
ID PR1B2_ARATH Reviewed; 213 AA.
AC Q9SIY7; Q680Y9;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=PRA1 family protein B2;
DE Short=AtPRA1.B2;
GN Name=PRA1B2; OrderedLocusNames=At2g40380; ORFNames=T3G21.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP SUBCELLULAR LOCATION, INTERACTION WITH PRA1B1; PRA1B3; PRA1B4; PRA1B5;
RP PRA1B6 AND PRA1E, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18583532; DOI=10.1104/pp.108.122226;
RA Alvim Kamei C.L., Boruc J., Vandepoele K., Van den Daele H., Maes S.,
RA Russinova E., Inze D., de Veylder L.;
RT "The PRA1 gene family in Arabidopsis.";
RL Plant Physiol. 147:1735-1749(2008).
CC -!- FUNCTION: May be involved in both secretory and endocytic intracellular
CC trafficking in the endosomal/prevacuolar compartments. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PRA1B1, PRA1B3, PRA1B4, PRA1B5, PRA1B6 and
CC PRA1E. {ECO:0000269|PubMed:18583532}.
CC -!- INTERACTION:
CC Q9SIY7; Q9M012: PRA1B5; NbExp=4; IntAct=EBI-4426093, EBI-4430098;
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18583532};
CC Multi-pass membrane protein {ECO:0000269|PubMed:18583532}.
CC -!- SIMILARITY: Belongs to the PRA1 family. {ECO:0000305}.
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DR EMBL; AC007020; AAD25672.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09820.1; -; Genomic_DNA.
DR EMBL; BT010639; AAQ89661.1; -; mRNA.
DR EMBL; AK175728; BAD43491.1; -; mRNA.
DR EMBL; AK176230; BAD43993.1; -; mRNA.
DR PIR; G84828; G84828.
DR RefSeq; NP_181569.1; NM_129598.4.
DR AlphaFoldDB; Q9SIY7; -.
DR BioGRID; 3969; 20.
DR IntAct; Q9SIY7; 19.
DR STRING; 3702.AT2G40380.1; -.
DR PaxDb; Q9SIY7; -.
DR PRIDE; Q9SIY7; -.
DR ProteomicsDB; 234874; -.
DR EnsemblPlants; AT2G40380.1; AT2G40380.1; AT2G40380.
DR GeneID; 818631; -.
DR Gramene; AT2G40380.1; AT2G40380.1; AT2G40380.
DR KEGG; ath:AT2G40380; -.
DR Araport; AT2G40380; -.
DR TAIR; locus:2063120; AT2G40380.
DR eggNOG; KOG3142; Eukaryota.
DR HOGENOM; CLU_060198_1_0_1; -.
DR InParanoid; Q9SIY7; -.
DR OMA; SWMFLYL; -.
DR OrthoDB; 1344798at2759; -.
DR PhylomeDB; Q9SIY7; -.
DR PRO; PR:Q9SIY7; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SIY7; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0005768; C:endosome; HDA:TAIR.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0000138; C:Golgi trans cisterna; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; HDA:TAIR.
DR GO; GO:0016192; P:vesicle-mediated transport; IDA:TAIR.
DR InterPro; IPR004895; Prenylated_rab_accept_PRA1.
DR PANTHER; PTHR19317; PTHR19317; 1.
DR Pfam; PF03208; PRA1; 1.
PE 1: Evidence at protein level;
KW Endosome; Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..213
FT /note="PRA1 family protein B2"
FT /id="PRO_0000352251"
FT TRANSMEM 75..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 213 AA; 23159 MW; 465E9462A47F3B4A CRC64;
MSSSPAILPV TNQQAATQSQ PPINSHAFRT FLSRLSSSLR ESLSQRRPWL ELVDRSSFAR
PDSLTDSFSR IRKNLAYFKV NYSAIVSLVL AFSLLSHPFS LLVLLSLLGS WMFLYLFRSS
DQPLVLFGRS FSDRETLLGL VLTTIVVVFM TSVGSLLTSA LTIGIAIVCL HGAFRVPDDL
FLDEQEPANA GLLSFIGNSA ATSAAASVVA GRV
