PR1B4_ARATH
ID PR1B4_ARATH Reviewed; 220 AA.
AC O80915;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=PRA1 family protein B4;
DE Short=AtPRA1.B4;
GN Name=PRA1B4; OrderedLocusNames=At2g38360; ORFNames=T19C21.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH PRA1B1; PRA1B2;
RP PRA1B3; PRA1B5; PRA1B6 AND PRA1E, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18583532; DOI=10.1104/pp.108.122226;
RA Alvim Kamei C.L., Boruc J., Vandepoele K., Van den Daele H., Maes S.,
RA Russinova E., Inze D., de Veylder L.;
RT "The PRA1 gene family in Arabidopsis.";
RL Plant Physiol. 147:1735-1749(2008).
CC -!- FUNCTION: May be involved in both secretory and endocytic intracellular
CC trafficking in the endosomal/prevacuolar compartments. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PRA1B1, PRA1B2, PRA1B3, PRA1B5, PRA1B6 and
CC PRA1E. {ECO:0000269|PubMed:18583532}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18583532};
CC Multi-pass membrane protein {ECO:0000269|PubMed:18583532}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, lateral roots, lateral root
CC caps, stomata and trichomes. {ECO:0000269|PubMed:18583532}.
CC -!- SIMILARITY: Belongs to the PRA1 family. {ECO:0000305}.
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DR EMBL; AC004683; AAC28768.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09527.1; -; Genomic_DNA.
DR EMBL; BT010689; AAR20746.1; -; mRNA.
DR EMBL; BT011785; AAS68109.1; -; mRNA.
DR EMBL; AK229076; BAF00957.1; -; mRNA.
DR PIR; T02509; T02509.
DR RefSeq; NP_181370.1; NM_129392.4.
DR AlphaFoldDB; O80915; -.
DR BioGRID; 3758; 7.
DR IntAct; O80915; 7.
DR STRING; 3702.AT2G38360.1; -.
DR PaxDb; O80915; -.
DR PRIDE; O80915; -.
DR ProteomicsDB; 234843; -.
DR EnsemblPlants; AT2G38360.1; AT2G38360.1; AT2G38360.
DR GeneID; 818416; -.
DR Gramene; AT2G38360.1; AT2G38360.1; AT2G38360.
DR KEGG; ath:AT2G38360; -.
DR Araport; AT2G38360; -.
DR TAIR; locus:2057197; AT2G38360.
DR eggNOG; KOG3142; Eukaryota.
DR HOGENOM; CLU_060198_1_0_1; -.
DR InParanoid; O80915; -.
DR OMA; GEMCQRV; -.
DR OrthoDB; 1344798at2759; -.
DR PhylomeDB; O80915; -.
DR PRO; PR:O80915; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O80915; baseline and differential.
DR Genevisible; O80915; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0005768; C:endosome; HDA:TAIR.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; HDA:TAIR.
DR GO; GO:0016192; P:vesicle-mediated transport; IDA:TAIR.
DR InterPro; IPR004895; Prenylated_rab_accept_PRA1.
DR PANTHER; PTHR19317; PTHR19317; 1.
DR Pfam; PF03208; PRA1; 1.
PE 1: Evidence at protein level;
KW Endosome; Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..220
FT /note="PRA1 family protein B4"
FT /id="PRO_0000352253"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 220 AA; 23671 MW; 30ACB0883E86FF23 CRC64;
MASSAPPVLP ISNPQTVPSA APSSVESQPP IATPAFRNFI NQITETVKNG LSKRRPWAEL
ADRSALSKPE SISDAAVRIR KNYSYFKVNY LTVATAIVGF SLVTHPFSLV FLLCLLASWL
FLYLFRPTDQ PIVLFGRTFS DRETLGCLIL FSIFVIFLTD VGSVLVSAMM IGVALICAHG
AFRAPEDLFL DEQEPAATGF LSFLGGAASS AAPAVIAARV
