PR20A_HUMAN
ID PR20A_HUMAN Reviewed; 221 AA.
AC P86496; Q8N7V5;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Proline-rich protein 20A {ECO:0000305};
GN Name=PRR20A; Synonyms=PRR20;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the PRR20 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK097615; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL353652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC120931; AAI20932.1; -; mRNA.
DR EMBL; BC120932; AAI20933.1; -; mRNA.
DR CCDS; CCDS31981.1; -.
DR RefSeq; NP_001123876.1; NM_001130404.1.
DR RefSeq; NP_001123877.1; NM_001130405.1.
DR RefSeq; NP_001123878.1; NM_001130406.1.
DR RefSeq; NP_001123879.1; NM_001130407.1.
DR RefSeq; NP_940843.1; NM_198441.2.
DR RefSeq; XP_016855016.1; XM_016999527.1.
DR AlphaFoldDB; P86496; -.
DR BioGRID; 125761; 149.
DR BioGRID; 609637; 90.
DR BioGRID; 609643; 90.
DR BioGRID; 609649; 90.
DR BioGRID; 609653; 101.
DR STRING; 9606.ENSP00000367163; -.
DR iPTMnet; P86496; -.
DR PhosphoSitePlus; P86496; -.
DR BioMuta; PRR20A; -.
DR PaxDb; P86496; -.
DR PRIDE; P86496; -.
DR Antibodypedia; 67109; 18 antibodies from 7 providers.
DR DNASU; 122183; -.
DR Ensembl; ENST00000377931.1; ENSP00000367164.1; ENSG00000204919.1.
DR GeneID; 122183; -.
DR GeneID; 729233; -.
DR GeneID; 729240; -.
DR GeneID; 729246; -.
DR GeneID; 729250; -.
DR KEGG; hsa:122183; -.
DR KEGG; hsa:729233; -.
DR KEGG; hsa:729240; -.
DR KEGG; hsa:729246; -.
DR KEGG; hsa:729250; -.
DR MANE-Select; ENST00000377930.1; ENSP00000367163.1; NM_001130404.1; NP_001123876.1.
DR MANE-Select; ENST00000377931.1; ENSP00000367164.1; NM_198441.2; NP_940843.1.
DR MANE-Select; ENST00000434815.1; ENSP00000404281.1; NM_001130407.1; NP_001123879.1.
DR MANE-Select; ENST00000452123.3; ENSP00000392407.2; NM_001130406.1; NP_001123878.1.
DR MANE-Select; ENST00000544357.2; ENSP00000438757.1; NM_001130405.1; NP_001123877.1.
DR UCSC; uc010thd.1; human.
DR CTD; 122183; -.
DR CTD; 729233; -.
DR CTD; 729240; -.
DR CTD; 729246; -.
DR CTD; 729250; -.
DR GeneCards; PRR20A; -.
DR HGNC; HGNC:24754; PRR20A.
DR HPA; ENSG00000204919; Not detected.
DR neXtProt; NX_P86496; -.
DR OpenTargets; ENSG00000204919; -.
DR PharmGKB; PA165505473; -.
DR VEuPathDB; HostDB:ENSG00000204919; -.
DR eggNOG; ENOG502TFGJ; Eukaryota.
DR GeneTree; ENSGT00390000001542; -.
DR HOGENOM; CLU_117010_0_0_1; -.
DR InParanoid; P86496; -.
DR OMA; GRPTEPF; -.
DR OrthoDB; 1355106at2759; -.
DR PhylomeDB; P86496; -.
DR TreeFam; TF341860; -.
DR PathwayCommons; P86496; -.
DR BioGRID-ORCS; 122183; 16 hits in 551 CRISPR screens.
DR BioGRID-ORCS; 729233; 7 hits in 154 CRISPR screens.
DR BioGRID-ORCS; 729240; 7 hits in 150 CRISPR screens.
DR BioGRID-ORCS; 729246; 8 hits in 161 CRISPR screens.
DR BioGRID-ORCS; 729250; 10 hits in 193 CRISPR screens.
DR Pharos; P86496; Tdark.
DR PRO; PR:P86496; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; P86496; protein.
DR Genevisible; P86496; HS.
DR InterPro; IPR031439; PRR20.
DR PANTHER; PTHR38819; PTHR38819; 1.
DR Pfam; PF15708; PRR20; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..221
FT /note="Proline-rich protein 20A"
FT /id="PRO_0000336092"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 221 AA; 23262 MW; E870312E6F1D607F CRC64;
MEEPRPSKRL RSMAPNQASG GPPPEPGCCV ADPEGSVEAD GPAQPAQPAK PIAYVKPFRR
QPPARPESPP PAERGRRRGG SRRPGRGRGR RAGPRGDAGQ RQGAEGLMAP DVHIQLDHHG
EPGHQGEPEI TETAAFSLSE TGPPPGTVQE GPGPDVAQPE LGFQEPPAAP GPQAVDWQPV
LTLYPCIGFR ALGDSAVLQV IQTPQGTYVQ GVPVFLTDIA Y
