ID   PR20C_HUMAN             Reviewed;         221 AA.
AC   P86479; Q8N7V5;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Proline-rich protein 20C {ECO:0000305};
GN   Name=PRR20C {ECO:0000312|HGNC:HGNC:37221};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
CC   -!- INTERACTION:
CC       P86479; P54253: ATXN1; NbExp=3; IntAct=EBI-10172814, EBI-930964;
CC       P86479; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-10172814, EBI-946029;
CC       P86479; O75553: DAB1; NbExp=3; IntAct=EBI-10172814, EBI-7875264;
CC       P86479; Q15038: DAZAP2; NbExp=4; IntAct=EBI-10172814, EBI-724310;
CC       P86479; Q92567: FAM168A; NbExp=3; IntAct=EBI-10172814, EBI-7957930;
CC       P86479; Q9BZS1: FOXP3; NbExp=4; IntAct=EBI-10172814, EBI-983719;
CC       P86479; P23769: GATA2; NbExp=3; IntAct=EBI-10172814, EBI-2806671;
CC       P86479; Q9BRA0: NAA38; NbExp=3; IntAct=EBI-10172814, EBI-9106509;
CC       P86479; O43639: NCK2; NbExp=3; IntAct=EBI-10172814, EBI-713635;
CC       P86479; Q14511: NEDD9; NbExp=3; IntAct=EBI-10172814, EBI-2108053;
CC       P86479; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-10172814, EBI-1389308;
CC       P86479; Q93062: RBPMS; NbExp=3; IntAct=EBI-10172814, EBI-740322;
CC       P86479; A1L4F5: ROR2; NbExp=3; IntAct=EBI-10172814, EBI-10172778;
CC       P86479; P59797: SELENOV; NbExp=3; IntAct=EBI-10172814, EBI-10216195;
CC       P86479; Q8IUQ4: SIAH1; NbExp=5; IntAct=EBI-10172814, EBI-747107;
CC       P86479; P35711: SOX5; NbExp=3; IntAct=EBI-10172814, EBI-3505701;
CC       P86479; Q02446: SP4; NbExp=5; IntAct=EBI-10172814, EBI-10198587;
CC       P86479; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-10172814, EBI-741515;
CC       P86479; Q6FIE9: TOLLIP; NbExp=3; IntAct=EBI-10172814, EBI-10249783;
CC       P86479; Q08AM6: VAC14; NbExp=3; IntAct=EBI-10172814, EBI-2107455;
CC       P86479; Q96K80: ZC3H10; NbExp=3; IntAct=EBI-10172814, EBI-742550;
CC       P86479; Q96MN9: ZNF488; NbExp=3; IntAct=EBI-10172814, EBI-948288;
CC   -!- SIMILARITY: Belongs to the PRR20 family. {ECO:0000305}.
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DR   EMBL; AL353652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS45054.1; -.
DR   RefSeq; NP_001123876.1; NM_001130404.1.
DR   RefSeq; NP_001123877.1; NM_001130405.1.
DR   RefSeq; NP_001123878.1; NM_001130406.1.
DR   RefSeq; NP_001123879.1; NM_001130407.1.
DR   RefSeq; NP_940843.1; NM_198441.2.
DR   RefSeq; XP_016855016.1; XM_016999527.1.
DR   AlphaFoldDB; P86479; -.
DR   BioGRID; 125761; 149.
DR   BioGRID; 609637; 90.
DR   BioGRID; 609643; 90.
DR   BioGRID; 609649; 90.
DR   BioGRID; 609653; 101.
DR   IntAct; P86479; 26.
DR   iPTMnet; P86479; -.
DR   PhosphoSitePlus; P86479; -.
DR   BioMuta; PRR20C; -.
DR   PRIDE; P86479; -.
DR   DNASU; 122183; -.
DR   Ensembl; ENST00000544357.2; ENSP00000438757.1; ENSG00000229665.8.
DR   Ensembl; ENST00000614894.4; ENSP00000480729.1; ENSG00000229665.8.
DR   GeneID; 122183; -.
DR   GeneID; 729233; -.
DR   GeneID; 729240; -.
DR   GeneID; 729246; -.
DR   GeneID; 729250; -.
DR   KEGG; hsa:122183; -.
DR   KEGG; hsa:729233; -.
DR   KEGG; hsa:729240; -.
DR   KEGG; hsa:729246; -.
DR   KEGG; hsa:729250; -.
DR   MANE-Select; ENST00000377930.1; ENSP00000367163.1; NM_001130404.1; NP_001123876.1.
DR   MANE-Select; ENST00000377931.1; ENSP00000367164.1; NM_198441.2; NP_940843.1.
DR   MANE-Select; ENST00000434815.1; ENSP00000404281.1; NM_001130407.1; NP_001123879.1.
DR   MANE-Select; ENST00000452123.3; ENSP00000392407.2; NM_001130406.1; NP_001123878.1.
DR   MANE-Select; ENST00000544357.2; ENSP00000438757.1; NM_001130405.1; NP_001123877.1.
DR   CTD; 122183; -.
DR   CTD; 729233; -.
DR   CTD; 729240; -.
DR   CTD; 729246; -.
DR   CTD; 729250; -.
DR   GeneCards; PRR20C; -.
DR   HGNC; HGNC:37221; PRR20C.
DR   HPA; ENSG00000229665; Not detected.
DR   neXtProt; NX_P86479; -.
DR   OpenTargets; ENSG00000204919; -.
DR   PharmGKB; PA165505473; -.
DR   VEuPathDB; HostDB:ENSG00000229665; -.
DR   HOGENOM; CLU_117010_0_0_1; -.
DR   InParanoid; P86479; -.
DR   OMA; PNGTYVQ; -.
DR   OrthoDB; 1355106at2759; -.
DR   PhylomeDB; P86479; -.
DR   TreeFam; TF341860; -.
DR   PathwayCommons; P86479; -.
DR   SignaLink; P86479; -.
DR   BioGRID-ORCS; 122183; 16 hits in 551 CRISPR screens.
DR   BioGRID-ORCS; 729233; 7 hits in 154 CRISPR screens.
DR   BioGRID-ORCS; 729240; 7 hits in 150 CRISPR screens.
DR   BioGRID-ORCS; 729246; 8 hits in 161 CRISPR screens.
DR   BioGRID-ORCS; 729250; 10 hits in 193 CRISPR screens.
DR   Pharos; P86479; Tdark.
DR   PRO; PR:P86479; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; P86479; protein.
DR   Bgee; ENSG00000229665; Expressed in testis and 1 other tissue.
DR   Genevisible; P86479; HS.
DR   InterPro; IPR031439; PRR20.
DR   PANTHER; PTHR38819; PTHR38819; 1.
DR   Pfam; PF15708; PRR20; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..221
FT                   /note="Proline-rich protein 20C"
FT                   /id="PRO_0000393892"
FT   REGION          1..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          137..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   221 AA;  23262 MW;  E870312E6F1D607F CRC64;
     MEEPRPSKRL RSMAPNQASG GPPPEPGCCV ADPEGSVEAD GPAQPAQPAK PIAYVKPFRR
     QPPARPESPP PAERGRRRGG SRRPGRGRGR RAGPRGDAGQ RQGAEGLMAP DVHIQLDHHG
     EPGHQGEPEI TETAAFSLSE TGPPPGTVQE GPGPDVAQPE LGFQEPPAAP GPQAVDWQPV
     LTLYPCIGFR ALGDSAVLQV IQTPQGTYVQ GVPVFLTDIA Y