PR20D_HUMAN
ID PR20D_HUMAN Reviewed; 221 AA.
AC P86480; Q8N7V5;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Proline-rich protein 20D {ECO:0000305};
GN Name=PRR20D {ECO:0000312|HGNC:HGNC:37222};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
CC -!- INTERACTION:
CC P86480; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-12754095, EBI-11096309;
CC P86480; Q8IWG5: ANKHD1; NbExp=3; IntAct=EBI-12754095, EBI-355540;
CC P86480; Q03989: ARID5A; NbExp=3; IntAct=EBI-12754095, EBI-948603;
CC P86480; P54253: ATXN1; NbExp=3; IntAct=EBI-12754095, EBI-930964;
CC P86480; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-12754095, EBI-11524452;
CC P86480; Q8NDZ0: BEND2; NbExp=3; IntAct=EBI-12754095, EBI-954079;
CC P86480; O14503: BHLHE40; NbExp=3; IntAct=EBI-12754095, EBI-711810;
CC P86480; Q6AI39: BICRAL; NbExp=3; IntAct=EBI-12754095, EBI-1012434;
CC P86480; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-12754095, EBI-12809220;
CC P86480; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-12754095, EBI-946029;
CC P86480; Q3SXR2: C3orf36; NbExp=3; IntAct=EBI-12754095, EBI-18036948;
CC P86480; Q9NPB3: CABP2; NbExp=3; IntAct=EBI-12754095, EBI-12011224;
CC P86480; O75909-2: CCNK; NbExp=3; IntAct=EBI-12754095, EBI-12010594;
CC P86480; Q16543: CDC37; NbExp=3; IntAct=EBI-12754095, EBI-295634;
CC P86480; Q9BZC1-2: CELF4; NbExp=3; IntAct=EBI-12754095, EBI-12818201;
CC P86480; Q15038: DAZAP2; NbExp=5; IntAct=EBI-12754095, EBI-724310;
CC P86480; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-12754095, EBI-9679045;
CC P86480; Q92997: DVL3; NbExp=3; IntAct=EBI-12754095, EBI-739789;
CC P86480; Q9NRA8: EIF4ENIF1; NbExp=3; IntAct=EBI-12754095, EBI-301024;
CC P86480; Q6NXG1: ESRP1; NbExp=3; IntAct=EBI-12754095, EBI-10213520;
CC P86480; Q92567-2: FAM168A; NbExp=3; IntAct=EBI-12754095, EBI-11978259;
CC P86480; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-12754095, EBI-2807642;
CC P86480; Q8IZU1: FAM9A; NbExp=3; IntAct=EBI-12754095, EBI-8468186;
CC P86480; O75593: FOXH1; NbExp=3; IntAct=EBI-12754095, EBI-1759806;
CC P86480; Q9BZS1: FOXP3; NbExp=4; IntAct=EBI-12754095, EBI-983719;
CC P86480; Q9BZE0: GLIS2; NbExp=3; IntAct=EBI-12754095, EBI-7251368;
CC P86480; P52655: GTF2A1; NbExp=3; IntAct=EBI-12754095, EBI-389518;
CC P86480; A0A024R5S0: hCG_2003792; NbExp=3; IntAct=EBI-12754095, EBI-10188461;
CC P86480; Q14774: HLX; NbExp=3; IntAct=EBI-12754095, EBI-6678255;
CC P86480; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-12754095, EBI-12811111;
CC P86480; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-12754095, EBI-1048945;
CC P86480; Q14847-2: LASP1; NbExp=3; IntAct=EBI-12754095, EBI-9088686;
CC P86480; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-12754095, EBI-716006;
CC P86480; Q9NUK0-3: MBNL3; NbExp=3; IntAct=EBI-12754095, EBI-12049233;
CC P86480; O43639: NCK2; NbExp=3; IntAct=EBI-12754095, EBI-713635;
CC P86480; Q13952-2: NFYC; NbExp=3; IntAct=EBI-12754095, EBI-11956831;
CC P86480; Q9UM47: NOTCH3; NbExp=3; IntAct=EBI-12754095, EBI-1236377;
CC P86480; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12754095, EBI-741158;
CC P86480; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-12754095, EBI-12813389;
CC P86480; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-12754095, EBI-11022007;
CC P86480; O43189: PHF1; NbExp=5; IntAct=EBI-12754095, EBI-530034;
CC P86480; P78337: PITX1; NbExp=3; IntAct=EBI-12754095, EBI-748265;
CC P86480; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-12754095, EBI-1389308;
CC P86480; P14859-6: POU2F1; NbExp=3; IntAct=EBI-12754095, EBI-11526590;
CC P86480; P78424: POU6F2; NbExp=3; IntAct=EBI-12754095, EBI-12029004;
CC P86480; P86480: PRR20D; NbExp=3; IntAct=EBI-12754095, EBI-12754095;
CC P86480; Q9NV39: PRR34; NbExp=6; IntAct=EBI-12754095, EBI-11959565;
CC P86480; P0CG20: PRR35; NbExp=3; IntAct=EBI-12754095, EBI-11986293;
CC P86480; Q9NZH5-2: PTTG2; NbExp=3; IntAct=EBI-12754095, EBI-17630019;
CC P86480; Q9BTD8: RBM42; NbExp=3; IntAct=EBI-12754095, EBI-746862;
CC P86480; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-12754095, EBI-740343;
CC P86480; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-12754095, EBI-11987469;
CC P86480; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-12754095, EBI-372094;
CC P86480; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-12754095, EBI-10226430;
CC P86480; P78317: RNF4; NbExp=3; IntAct=EBI-12754095, EBI-2340927;
CC P86480; Q01974: ROR2; NbExp=3; IntAct=EBI-12754095, EBI-6422642;
CC P86480; Q96NU1: SAMD11; NbExp=3; IntAct=EBI-12754095, EBI-14067109;
CC P86480; Q8IUQ4-2: SIAH1; NbExp=3; IntAct=EBI-12754095, EBI-11522811;
CC P86480; Q8IYB5-2: SMAP1; NbExp=6; IntAct=EBI-12754095, EBI-12061577;
CC P86480; P14678-2: SNRPB; NbExp=3; IntAct=EBI-12754095, EBI-372475;
CC P86480; P09234: SNRPC; NbExp=3; IntAct=EBI-12754095, EBI-766589;
CC P86480; Q02446: SP4; NbExp=3; IntAct=EBI-12754095, EBI-10198587;
CC P86480; P78362: SRPK2; NbExp=3; IntAct=EBI-12754095, EBI-593303;
CC P86480; O15119: TBX3; NbExp=3; IntAct=EBI-12754095, EBI-3452216;
CC P86480; O95947: TBX6; NbExp=3; IntAct=EBI-12754095, EBI-2824328;
CC P86480; Q9NQB0-10: TCF7L2; NbExp=3; IntAct=EBI-12754095, EBI-11746252;
CC P86480; Q92734: TFG; NbExp=3; IntAct=EBI-12754095, EBI-357061;
CC P86480; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-12754095, EBI-741515;
CC P86480; Q01085-2: TIAL1; NbExp=3; IntAct=EBI-12754095, EBI-11064654;
CC P86480; O43711: TLX3; NbExp=3; IntAct=EBI-12754095, EBI-3939165;
CC P86480; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-12754095, EBI-74615;
CC P86480; Q8N7U7-2: TPRX1; NbExp=3; IntAct=EBI-12754095, EBI-14115717;
CC P86480; Q9UPQ4-2: TRIM35; NbExp=3; IntAct=EBI-12754095, EBI-17716262;
CC P86480; Q08AM6: VAC14; NbExp=3; IntAct=EBI-12754095, EBI-2107455;
CC P86480; O95231: VENTX; NbExp=3; IntAct=EBI-12754095, EBI-10191303;
CC P86480; Q14119: VEZF1; NbExp=3; IntAct=EBI-12754095, EBI-11980193;
CC P86480; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-12754095, EBI-2559305;
CC P86480; A0A0C4DGF1: ZBTB32; NbExp=3; IntAct=EBI-12754095, EBI-10188476;
CC P86480; Q96K80: ZC3H10; NbExp=3; IntAct=EBI-12754095, EBI-742550;
CC P86480; Q8WYQ9: ZCCHC14; NbExp=3; IntAct=EBI-12754095, EBI-3937908;
CC P86480; Q66K41-2: ZNF385C; NbExp=3; IntAct=EBI-12754095, EBI-12055653;
CC P86480; Q8IZ20: ZNF683; NbExp=3; IntAct=EBI-12754095, EBI-12005952;
CC P86480; B2RDP1; NbExp=3; IntAct=EBI-12754095, EBI-18956102;
CC -!- SIMILARITY: Belongs to the PRR20 family. {ECO:0000305}.
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DR EMBL; AL353652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45055.1; -.
DR RefSeq; NP_001123876.1; NM_001130404.1.
DR RefSeq; NP_001123877.1; NM_001130405.1.
DR RefSeq; NP_001123878.1; NM_001130406.1.
DR RefSeq; NP_001123879.1; NM_001130407.1.
DR RefSeq; NP_940843.1; NM_198441.2.
DR RefSeq; XP_016855016.1; XM_016999527.1.
DR AlphaFoldDB; P86480; -.
DR BioGRID; 125761; 149.
DR BioGRID; 609637; 90.
DR BioGRID; 609643; 90.
DR BioGRID; 609649; 90.
DR BioGRID; 609653; 101.
DR IntAct; P86480; 82.
DR iPTMnet; P86480; -.
DR PhosphoSitePlus; P86480; -.
DR BioMuta; PRR20D; -.
DR DNASU; 122183; -.
DR Ensembl; ENST00000452123.3; ENSP00000392407.2; ENSG00000227151.4.
DR GeneID; 122183; -.
DR GeneID; 729233; -.
DR GeneID; 729240; -.
DR GeneID; 729246; -.
DR GeneID; 729250; -.
DR KEGG; hsa:122183; -.
DR KEGG; hsa:729233; -.
DR KEGG; hsa:729240; -.
DR KEGG; hsa:729246; -.
DR KEGG; hsa:729250; -.
DR MANE-Select; ENST00000377930.1; ENSP00000367163.1; NM_001130404.1; NP_001123876.1.
DR MANE-Select; ENST00000377931.1; ENSP00000367164.1; NM_198441.2; NP_940843.1.
DR MANE-Select; ENST00000434815.1; ENSP00000404281.1; NM_001130407.1; NP_001123879.1.
DR MANE-Select; ENST00000452123.3; ENSP00000392407.2; NM_001130406.1; NP_001123878.1.
DR MANE-Select; ENST00000544357.2; ENSP00000438757.1; NM_001130405.1; NP_001123877.1.
DR CTD; 122183; -.
DR CTD; 729233; -.
DR CTD; 729240; -.
DR CTD; 729246; -.
DR CTD; 729250; -.
DR GeneCards; PRR20D; -.
DR HGNC; HGNC:37222; PRR20D.
DR HPA; ENSG00000227151; Not detected.
DR neXtProt; NX_P86480; -.
DR OpenTargets; ENSG00000204919; -.
DR PharmGKB; PA165505473; -.
DR VEuPathDB; HostDB:ENSG00000227151; -.
DR HOGENOM; CLU_117010_0_0_1; -.
DR InParanoid; P86480; -.
DR OrthoDB; 1355106at2759; -.
DR PhylomeDB; P86480; -.
DR TreeFam; TF341860; -.
DR PathwayCommons; P86480; -.
DR SignaLink; P86480; -.
DR BioGRID-ORCS; 122183; 16 hits in 551 CRISPR screens.
DR BioGRID-ORCS; 729233; 7 hits in 154 CRISPR screens.
DR BioGRID-ORCS; 729240; 7 hits in 150 CRISPR screens.
DR BioGRID-ORCS; 729246; 8 hits in 161 CRISPR screens.
DR BioGRID-ORCS; 729250; 10 hits in 193 CRISPR screens.
DR Pharos; P86480; Tdark.
DR PRO; PR:P86480; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; P86480; protein.
DR Genevisible; P86480; HS.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR031439; PRR20.
DR PANTHER; PTHR38819; PTHR38819; 1.
DR Pfam; PF15708; PRR20; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..221
FT /note="Proline-rich protein 20D"
FT /id="PRO_0000393891"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 221 AA; 23262 MW; E870312E6F1D607F CRC64;
MEEPRPSKRL RSMAPNQASG GPPPEPGCCV ADPEGSVEAD GPAQPAQPAK PIAYVKPFRR
QPPARPESPP PAERGRRRGG SRRPGRGRGR RAGPRGDAGQ RQGAEGLMAP DVHIQLDHHG
EPGHQGEPEI TETAAFSLSE TGPPPGTVQE GPGPDVAQPE LGFQEPPAAP GPQAVDWQPV
LTLYPCIGFR ALGDSAVLQV IQTPQGTYVQ GVPVFLTDIA Y
