ID   PR23A_HUMAN             Reviewed;         266 AA.
AC   A6NEV1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Proline-rich protein 23A;
GN   Name=PRR23A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
CC   -!- SIMILARITY: Belongs to the PRR23 family. {ECO:0000305}.
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DR   EMBL; AC130416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS46923.1; -.
DR   RefSeq; NP_001128131.1; NM_001134659.1.
DR   AlphaFoldDB; A6NEV1; -.
DR   STRING; 9606.ENSP00000372649; -.
DR   iPTMnet; A6NEV1; -.
DR   PhosphoSitePlus; A6NEV1; -.
DR   BioMuta; PRR23A; -.
DR   PaxDb; A6NEV1; -.
DR   PeptideAtlas; A6NEV1; -.
DR   PRIDE; A6NEV1; -.
DR   Antibodypedia; 68301; 62 antibodies from 13 providers.
DR   DNASU; 729627; -.
DR   Ensembl; ENST00000383163.4; ENSP00000372649.2; ENSG00000206260.4.
DR   GeneID; 729627; -.
DR   KEGG; hsa:729627; -.
DR   MANE-Select; ENST00000383163.4; ENSP00000372649.2; NM_001134659.1; NP_001128131.1.
DR   UCSC; uc011bms.3; human.
DR   CTD; 729627; -.
DR   DisGeNET; 729627; -.
DR   GeneCards; PRR23A; -.
DR   HGNC; HGNC:37172; PRR23A.
DR   HPA; ENSG00000206260; Tissue enhanced (testis).
DR   neXtProt; NX_A6NEV1; -.
DR   PharmGKB; PA165698130; -.
DR   VEuPathDB; HostDB:ENSG00000206260; -.
DR   eggNOG; ENOG502RU0G; Eukaryota.
DR   GeneTree; ENSGT00390000007772; -.
DR   HOGENOM; CLU_090685_0_0_1; -.
DR   InParanoid; A6NEV1; -.
DR   OMA; KRPPCKA; -.
DR   OrthoDB; 1423797at2759; -.
DR   PhylomeDB; A6NEV1; -.
DR   TreeFam; TF338612; -.
DR   PathwayCommons; A6NEV1; -.
DR   SignaLink; A6NEV1; -.
DR   BioGRID-ORCS; 729627; 10 hits in 1003 CRISPR screens.
DR   GenomeRNAi; 729627; -.
DR   Pharos; A6NEV1; Tdark.
DR   PRO; PR:A6NEV1; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; A6NEV1; protein.
DR   Bgee; ENSG00000206260; Expressed in right testis and 2 other tissues.
DR   InterPro; IPR018903; PRR23.
DR   Pfam; PF10630; DUF2476; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..266
FT                   /note="Proline-rich protein 23A"
FT                   /id="PRO_0000332252"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..252
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   266 AA;  28155 MW;  7DACDF068B9BF915 CRC64;
     MGSRPRSPSA FPAPWWGQQP GGPGPAKRLR LEEPAGPEPR VAPSLEDPAG TPAVGALTSI
     VVLAAGCALR VPLDDVDLVL ELPPTSILRV SLDGHTLILI PEVLLSSVDE RSGAQDDSSA
     GLEVDVFLGA LREDVVVEQE VFCASVPEIA AQEEAYEEDA DPEFPELQMD SAAGSAAGLY
     SSARSMFSPY REGPIPEPCA LAPNPSSEGH SPGPFFDPEF RLLEPVPSSP LQPLPPSPRV
     GSPGPHAHPP LPKRPPCKAR RRLFQE