PR23B_HUMAN
ID PR23B_HUMAN Reviewed; 265 AA.
AC Q6ZRT6; B2RNV9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Proline-rich protein 23B;
GN Name=PRR23B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6ZRT6; Q4LE39-3: ARID4B; NbExp=3; IntAct=EBI-12845180, EBI-11957452;
CC Q6ZRT6; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-12845180, EBI-11524452;
CC Q6ZRT6; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-12845180, EBI-6658203;
CC Q6ZRT6; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-12845180, EBI-11955401;
CC Q6ZRT6; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12845180, EBI-741158;
CC Q6ZRT6; O15231: ZNF185; NbExp=3; IntAct=EBI-12845180, EBI-6874731;
CC -!- SIMILARITY: Belongs to the PRR23 family. {ECO:0000305}.
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DR EMBL; AK127998; BAC87223.1; -; mRNA.
DR EMBL; BC137145; AAI37146.1; -; mRNA.
DR EMBL; BC137146; AAI37147.1; -; mRNA.
DR CCDS; CCDS33868.1; -.
DR RefSeq; NP_001013672.1; NM_001013650.2.
DR AlphaFoldDB; Q6ZRT6; -.
DR BioGRID; 133002; 7.
DR IntAct; Q6ZRT6; 6.
DR STRING; 9606.ENSP00000328768; -.
DR iPTMnet; Q6ZRT6; -.
DR PhosphoSitePlus; Q6ZRT6; -.
DR BioMuta; PRR23B; -.
DR DMDM; 74711249; -.
DR PaxDb; Q6ZRT6; -.
DR PeptideAtlas; Q6ZRT6; -.
DR PRIDE; Q6ZRT6; -.
DR DNASU; 389151; -.
DR Ensembl; ENST00000329447.5; ENSP00000328768.5; ENSG00000184814.5.
DR GeneID; 389151; -.
DR KEGG; hsa:389151; -.
DR MANE-Select; ENST00000329447.5; ENSP00000328768.5; NM_001013650.2; NP_001013672.1.
DR UCSC; uc003esy.1; human.
DR CTD; 389151; -.
DR GeneCards; PRR23B; -.
DR HGNC; HGNC:33764; PRR23B.
DR HPA; ENSG00000184814; Tissue enriched (testis).
DR neXtProt; NX_Q6ZRT6; -.
DR PharmGKB; PA165698144; -.
DR VEuPathDB; HostDB:ENSG00000184814; -.
DR eggNOG; ENOG502RU0G; Eukaryota.
DR GeneTree; ENSGT00390000007772; -.
DR HOGENOM; CLU_090685_0_0_1; -.
DR InParanoid; Q6ZRT6; -.
DR OMA; MFIPYRE; -.
DR OrthoDB; 1423797at2759; -.
DR PhylomeDB; Q6ZRT6; -.
DR TreeFam; TF338612; -.
DR PathwayCommons; Q6ZRT6; -.
DR SignaLink; Q6ZRT6; -.
DR BioGRID-ORCS; 389151; 12 hits in 1022 CRISPR screens.
DR GenomeRNAi; 389151; -.
DR Pharos; Q6ZRT6; Tdark.
DR PRO; PR:Q6ZRT6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6ZRT6; protein.
DR Bgee; ENSG00000184814; Expressed in right testis and 1 other tissue.
DR InterPro; IPR018903; PRR23.
DR Pfam; PF10630; DUF2476; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..265
FT /note="Proline-rich protein 23B"
FT /id="PRO_0000332251"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..251
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 265 AA; 28269 MW; EEC9F108642DAB0A CRC64;
MVSRPRSPSA FPAPWWGQQP GGPGPAKRLR LEEPAGPEPR AAPSLEDPAG DPAVDALTSI
VVLAAGCALR VPLDDVDLVL EPAPTSILRV SLGGHTLILI PEVLLSSVDE RSGAQHDSSA
GLEVDVFLGA VREDVVVELE FCASVPEIAA QEEAYEEDAD PEFPELRMDS PTGSAAGLYP
SSRSMFIPYR EGPIPEPCAL APNPSSERRS PRPIFDLEFR LLEPVPSSPL QPLPPSPCVG
SPGPHARSPL PERPPCKARR RLFQA
