PR28_MYCTU
ID PR28_MYCTU Reviewed; 310 AA.
AC P9WIM9; L0T5C1; P0A5Q6; P71697;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 33.
DE RecName: Full=Proline-rich 28 kDa antigen;
DE Flags: Precursor;
GN Name=mtc28; OrderedLocusNames=Rv0040c; ORFNames=MTCY21D4.03c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9393781; DOI=10.1128/iai.65.12.4951-4957.1997;
RA Manca C., Lyashchenko K., Colangeli R., Gennaro M.L.;
RT "MTC28, a novel 28-kilodalton proline-rich secreted antigen specific for
RT the Mycobacterium tuberculosis complex.";
RL Infect. Immun. 65:4951-4957(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [3]
RP SEQUENCE REVISION.
RX PubMed=12368430; DOI=10.1099/00221287-148-10-2967;
RA Camus J.-C., Pryor M.J., Medigue C., Cole S.T.;
RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis
RT H37Rv.";
RL Microbiology 148:2967-2973(2002).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SIMILARITY: To M.leprae ML0031. {ECO:0000305}.
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DR EMBL; U75271; AAB97625.1; -; Genomic_DNA.
DR EMBL; AL123456; CCP42762.1; -; Genomic_DNA.
DR PIR; H70911; H70911.
DR RefSeq; NP_214554.2; NC_000962.3.
DR RefSeq; WP_003900793.1; NZ_NVQJ01000005.1.
DR PDB; 4OL4; X-ray; 2.80 A; A=32-310.
DR PDB; 4PWS; X-ray; 2.15 A; A=32-310.
DR PDBsum; 4OL4; -.
DR PDBsum; 4PWS; -.
DR AlphaFoldDB; P9WIM9; -.
DR SMR; P9WIM9; -.
DR STRING; 83332.Rv0040c; -.
DR PaxDb; P9WIM9; -.
DR GeneID; 887037; -.
DR KEGG; mtu:Rv0040c; -.
DR TubercuList; Rv0040c; -.
DR eggNOG; ENOG5031EJ8; Bacteria.
DR OMA; RDFRALN; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR InterPro; IPR019674; Lipoprotein_LpqN/LpqT-like.
DR Pfam; PF10738; Lpp-LpqN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..310
FT /note="Proline-rich 28 kDa antigen"
FT /id="PRO_0000022094"
FT REGION 278..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..310
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 106..112
FT /evidence="ECO:0007829|PDB:4PWS"
FT STRAND 116..119
FT /evidence="ECO:0007829|PDB:4PWS"
FT STRAND 129..131
FT /evidence="ECO:0007829|PDB:4PWS"
FT STRAND 149..154
FT /evidence="ECO:0007829|PDB:4PWS"
FT STRAND 159..162
FT /evidence="ECO:0007829|PDB:4PWS"
FT STRAND 165..175
FT /evidence="ECO:0007829|PDB:4PWS"
FT HELIX 179..182
FT /evidence="ECO:0007829|PDB:4PWS"
FT HELIX 183..185
FT /evidence="ECO:0007829|PDB:4PWS"
FT HELIX 188..191
FT /evidence="ECO:0007829|PDB:4PWS"
FT STRAND 197..202
FT /evidence="ECO:0007829|PDB:4PWS"
FT STRAND 211..220
FT /evidence="ECO:0007829|PDB:4PWS"
FT STRAND 223..236
FT /evidence="ECO:0007829|PDB:4PWS"
FT STRAND 239..250
FT /evidence="ECO:0007829|PDB:4PWS"
FT HELIX 251..253
FT /evidence="ECO:0007829|PDB:4PWS"
FT TURN 254..257
FT /evidence="ECO:0007829|PDB:4PWS"
FT HELIX 258..267
FT /evidence="ECO:0007829|PDB:4PWS"
FT STRAND 269..271
FT /evidence="ECO:0007829|PDB:4PWS"
SQ SEQUENCE 310 AA; 31924 MW; 21BF447601916262 CRC64;
MIQIARTWRV FAGGMATGFI GVVLVTAGKA SADPLLPPPP IPAPVSAPAT VPPVQNLTAL
PGGSSNRFSP APAPAPIASP IPVGAPGSTA VPPLPPPVTP AISGTLRDHL REKGVKLEAQ
RPHGFKALDI TLPMPPRWTQ VPDPNVPDAF VVIADRLGNS VYTSNAQLVV YRLIGDFDPA
EAITHGYIDS QKLLAWQTTN ASMANFDGFP SSIIEGTYRE NDMTLNTSRR HVIATSGADK
YLVSLSVTTA LSQAVTDGPA TDAIVNGFQV VAHAAPAQAP APAPGSAPVG LPGQAPGYPP
AGTLTPVPPR
