PR2A1_MOUSE
ID PR2A1_MOUSE Reviewed; 228 AA.
AC Q9JHK0; Q9JI05;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Prolactin-2A1;
DE AltName: Full=Placental prolactin-like protein M;
DE Short=PLP-M;
DE Short=PRL-like protein M;
DE Flags: Precursor;
GN Name=Prl2a1; Synonyms=Prlpm;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Uterus;
RX PubMed=10471365; DOI=10.1006/bbrc.1999.1260;
RA Ishibashi K., Imai M.;
RT "Identification of four members of the rat prolactin/growth hormone gene
RT family.";
RL Biochem. Biophys. Res. Commun. 262:575-578(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10906059; DOI=10.1095/biolreprod63.2.519;
RA Toft D.J., Linzer D.I.H.;
RT "Identification of three prolactin-related hormones as markers of invasive
RT trophoblasts in the rat.";
RL Biol. Reprod. 63:519-525(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10856884; DOI=10.1677/joe.0.1660063;
RA Dai G., Wang D., Liu B., Kasik J.W., Mueller H., White R.A., Hummel G.S.,
RA Soares M.J.;
RT "Three novel paralogs of the rodent prolactin gene family.";
RL J. Endocrinol. 166:63-75(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=10922068; DOI=10.1073/pnas.97.16.9127;
RA Tanaka T.S., Jaradat S.A., Lim M.K., Kargul G.J., Wang X., Grahovac M.J.,
RA Pantano S., Sano Y., Piao Y., Nagaraja R., Doi H., Wood W.H. III,
RA Becker K.G., Ko M.S.H.;
RT "Genome-wide expression profiling of mid-gestation placenta and embryo
RT using a 15,000 mouse developmental cDNA microarray.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9127-9132(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed specifically in the placenta. Expression
CC restricted to the junctional zone of the chorioallantoic placenta.
CC {ECO:0000269|PubMed:10856884}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AB032428; BAB40452.1; -; mRNA.
DR EMBL; AF226610; AAF89999.1; -; mRNA.
DR EMBL; AF234636; AAF40435.1; -; mRNA.
DR EMBL; AF272368; AAF76230.1; -; mRNA.
DR EMBL; AK005424; BAB24018.1; -; mRNA.
DR EMBL; AL627326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC099458; AAH99458.1; -; mRNA.
DR CCDS; CCDS26407.1; -.
DR RefSeq; NP_064375.1; NM_019991.1.
DR AlphaFoldDB; Q9JHK0; -.
DR SMR; Q9JHK0; -.
DR STRING; 10090.ENSMUSP00000023602; -.
DR iPTMnet; Q9JHK0; -.
DR PhosphoSitePlus; Q9JHK0; -.
DR PaxDb; Q9JHK0; -.
DR PeptideAtlas; Q9JHK0; -.
DR PRIDE; Q9JHK0; -.
DR DNASU; 56635; -.
DR Ensembl; ENSMUST00000023602; ENSMUSP00000023602; ENSMUSG00000022886.
DR GeneID; 56635; -.
DR KEGG; mmu:56635; -.
DR UCSC; uc007pye.1; mouse.
DR CTD; 56635; -.
DR MGI; MGI:1861446; Prl2a1.
DR VEuPathDB; HostDB:ENSMUSG00000022886; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; Q9JHK0; -.
DR OMA; YTNILAC; -.
DR OrthoDB; 1290070at2759; -.
DR PhylomeDB; Q9JHK0; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 56635; 1 hit in 70 CRISPR screens.
DR PRO; PR:Q9JHK0; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9JHK0; protein.
DR Bgee; ENSMUSG00000022886; Expressed in ectoplacental cone and 9 other tissues.
DR ExpressionAtlas; Q9JHK0; baseline and differential.
DR Genevisible; Q9JHK0; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..228
FT /note="Prolactin-2A1"
FT /id="PRO_0000045161"
FT DISULFID 87..203
FT /evidence="ECO:0000250"
FT DISULFID 220..228
FT /evidence="ECO:0000250"
FT CONFLICT 136
FT /note="N -> T (in Ref. 4; AAF76230)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 228 AA; 25554 MW; 5307F93B013A8D97 CRC64;
MQLSVTHPCC RTLILLLVSN LLLWESEAVL PICSVRNGRC FGSFEELLER AVSLSEEISK
KAFELFTAFD SQYAQSHQLI VKSLKKCHTS SLDLPKPGSQ AMQTHPVTLL KLASKLLRAW
QVPLNHLVNN LPSLKNVSPS ILSKAKEIEE KSNGLLEGVK SILIQMQNGD TEDENYPGWS
GLASLKSETE DIRLFAYYNM IRCEGRDTQK VETALKMVKC KISNENNC
