ID   PR2A1_RAT               Reviewed;         228 AA.
AC   Q9JII3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Prolactin-2A1;
DE   AltName: Full=Placental prolactin-like protein M;
DE            Short=PLP-M;
DE            Short=PRL-like protein M;
DE   Flags: Precursor;
GN   Name=Prl2a1; Synonyms=Prlpm;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX   PubMed=10906059; DOI=10.1095/biolreprod63.2.519;
RA   Toft D.J., Linzer D.I.H.;
RT   "Identification of three prolactin-related hormones as markers of invasive
RT   trophoblasts in the rat.";
RL   Biol. Reprod. 63:519-525(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed specifically in the placenta. Highly
CC       expressed in invasive trophoblast cells lining the central placental
CC       vessel. {ECO:0000269|PubMed:10906059}.
CC   -!- DEVELOPMENTAL STAGE: Highest levels are observed from day 11 until
CC       parturition, with peak levels also on day 13.
CC       {ECO:0000269|PubMed:10906059}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF226608; AAF89997.1; -; mRNA.
DR   EMBL; BC097296; AAH97296.1; -; mRNA.
DR   RefSeq; NP_446243.1; NM_053791.2.
DR   AlphaFoldDB; Q9JII3; -.
DR   SMR; Q9JII3; -.
DR   STRING; 10116.ENSRNOP00000022093; -.
DR   PaxDb; Q9JII3; -.
DR   Ensembl; ENSRNOT00000022093; ENSRNOP00000022093; ENSRNOG00000016463.
DR   GeneID; 116474; -.
DR   KEGG; rno:116474; -.
DR   UCSC; RGD:620121; rat.
DR   CTD; 56635; -.
DR   RGD; 620121; Prl2a1.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   GeneTree; ENSGT00950000182818; -.
DR   HOGENOM; CLU_088274_0_1_1; -.
DR   InParanoid; Q9JII3; -.
DR   OMA; SATNSCH; -.
DR   OrthoDB; 1290070at2759; -.
DR   PhylomeDB; Q9JII3; -.
DR   TreeFam; TF332592; -.
DR   PRO; PR:Q9JII3; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Bgee; ENSRNOG00000016463; Expressed in colon.
DR   ExpressionAtlas; Q9JII3; baseline and differential.
DR   Genevisible; Q9JII3; RN.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..228
FT                   /note="Prolactin-2A1"
FT                   /id="PRO_0000045162"
FT   DISULFID        87..203
FT                   /evidence="ECO:0000250"
FT   DISULFID        220..228
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   228 AA;  25709 MW;  4806E49B60E61868 CRC64;
     MQLSITHPCC WTLRLLLVSN LLLWENVALV PTCLVRNGRC FASLEEMLER AVGLSEEISK
     QALQLFTEFD NQYAQSKQLI NKNFKKCHTS SLELPKPSST SVQTHPITLL KIASKLLSAW
     KVPLNDLVNN LPSLKDIHPN ILSKAREIEA KSAGLLEGVK SILIQMQNGD TEDENYPGWS
     GLASLQSENE DDRLFAYYNM IRCEGRETQK VETALKMVKC KISNENNC