ID   PR2B1_RAT               Reviewed;         228 AA.
AC   Q9JKL9; Q9R0R8;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Prolactin-2B1;
DE   AltName: Full=Placental prolactin-like protein K;
DE            Short=PLP-K;
DE            Short=PRL-like protein K;
DE   Flags: Precursor;
GN   Name=Prl2b1; Synonyms=Prlpk;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10471365; DOI=10.1006/bbrc.1999.1260;
RA   Ishibashi K., Imai M.;
RT   "Identification of four members of the rat prolactin/growth hormone gene
RT   family.";
RL   Biochem. Biophys. Res. Commun. 262:575-578(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=10856884; DOI=10.1677/joe.0.1660063;
RA   Dai G., Wang D., Liu B., Kasik J.W., Mueller H., White R.A., Hummel G.S.,
RA   Soares M.J.;
RT   "Three novel paralogs of the rodent prolactin gene family.";
RL   J. Endocrinol. 166:63-75(2000).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expression restricted to the placenta in
CC       trophoblast cells within the labyrinth zone.
CC       {ECO:0000269|PubMed:10856884}.
CC   -!- DEVELOPMENTAL STAGE: Expression initiated at midgestation.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AB022882; BAA84971.1; -; mRNA.
DR   EMBL; AF234635; AAF40434.1; -; mRNA.
DR   RefSeq; NP_620216.1; NM_138861.1.
DR   AlphaFoldDB; Q9JKL9; -.
DR   SMR; Q9JKL9; -.
DR   STRING; 10116.ENSRNOP00000022871; -.
DR   GlyGen; Q9JKL9; 1 site.
DR   iPTMnet; Q9JKL9; -.
DR   PhosphoSitePlus; Q9JKL9; -.
DR   PaxDb; Q9JKL9; -.
DR   GeneID; 192224; -.
DR   KEGG; rno:192224; -.
DR   UCSC; RGD:620118; rat.
DR   CTD; 66392; -.
DR   RGD; 620118; Prl2b1.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   InParanoid; Q9JKL9; -.
DR   OrthoDB; 1290070at2759; -.
DR   PhylomeDB; Q9JKL9; -.
DR   PRO; PR:Q9JKL9; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..228
FT                   /note="Prolactin-2B1"
FT                   /id="PRO_0000045170"
FT   CARBOHYD        173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        89..194
FT                   /evidence="ECO:0000250"
FT   DISULFID        203..228
FT                   /evidence="ECO:0000250"
FT   CONFLICT        158..161
FT                   /note="TTGV -> IDGC (in Ref. 2; AAF40434)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   228 AA;  26060 MW;  9D2241C0EF522DF6 CRC64;
     MLLYLPQIFS SRASSLLFLV PYLLFWENVA SISTCAERDA TIQHSLEKLL TLTTFMSHVM
     SIETAKLFTE FNNQYAQGKR YNDRIPGTCH TAFFDTPVNK EQSLGSDPKT LLKLVRSLLN
     SWTNALNHLV NEISAMQGDP SFLFSKAREI QAKFDELTTG VKTILSMIGE RDNDTHLAWS
     GLSSLQSSNE DVRCFSFYTL IRCLLRDSRK VNTYLEVIKY QIFNQNNC