PR2C5_MOUSE
ID PR2C5_MOUSE Reviewed; 222 AA.
AC Q9JLV9; Q3UKX5;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Prolactin-2C5 {ECO:0000305};
DE AltName: Full=Mitogen-regulated protein 4 {ECO:0000303|PubMed:10803597};
DE Flags: Precursor;
GN Name=Prl2c5 {ECO:0000312|MGI:MGI:1858413};
GN Synonyms=Mrp4 {ECO:0000303|PubMed:10803597, ECO:0000312|MGI:MGI:1858413},
GN Mrpplf4 {ECO:0000312|MGI:MGI:1858413}, Plf4 {ECO:0000312|MGI:MGI:1858413};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAF71815.1};
RN [1] {ECO:0000312|EMBL:AAF71815.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND GLYCOSYLATION.
RC STRAIN=CF-1 {ECO:0000312|EMBL:AAF71815.1};
RC TISSUE=Placenta {ECO:0000312|EMBL:AAF71815.1};
RX PubMed=10803597; DOI=10.1210/endo.141.5.7479;
RA Fassett J.T., Hamilton R.T., Nilsen-Hamilton M.;
RT "Mrp4, a new mitogen-regulated protein/proliferin gene; unique in this gene
RT family for its expression in the adult mouse tail and ear.";
RL Endocrinology 141:1863-1871(2000).
RN [2] {ECO:0000312|EMBL:BAE26676.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE26676.1};
RC TISSUE=Placenta {ECO:0000312|EMBL:BAE26676.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000312|EMBL:EDL20564.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000312|EMBL:AAI32515.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryo {ECO:0000312|EMBL:AAI32515.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6] {ECO:0000305}
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP GLYCOSYLATION.
RX PubMed=10537154; DOI=10.1210/endo.140.11.7142;
RA Fang Y., Lepont P., Fassett J.T., Ford S.P., Mubaidin A., Hamilton R.T.,
RA Nilsen-Hamilton M.;
RT "Signaling between the placenta and the uterus involving the mitogen-
RT regulated protein/proliferins.";
RL Endocrinology 140:5239-5249(1999).
RN [7] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=16876275; DOI=10.1016/j.neures.2006.05.011;
RA Wang J.W., Jiang Y.N., Huang C.Y., Huang P.Y., Huang M.C., Cheng W.T.,
RA Shen C.K., Ju Y.T.;
RT "Proliferin enhances microvilli formation and cell growth of neuroblastoma
RT cells.";
RL Neurosci. Res. 56:80-90(2006).
RN [8] {ECO:0000312|EMBL:CDW51417.1}
RP IDENTIFICATION.
RX PubMed=26697363; DOI=10.1016/j.gdata.2015.09.007;
RA Premzl M.;
RT "Third party data gene data set of eutherian growth hormone genes.";
RL Genom Data 6:166-169(2015).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10537154,
CC ECO:0000269|PubMed:10803597}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9JLV9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9JLV9-2; Sequence=VSP_058802;
CC -!- TISSUE SPECIFICITY: Expressed in placenta (at protein level)
CC (PubMed:10803597, PubMed:10537154, PubMed:16876275). Expressed in the
CC tail hair follicle, with highest expression detected in the
CC keratinocytes of the outer root sheath (PubMed:10803597). Expressed in
CC ear skin with lesser amounts in small intestine (PubMed:10803597). Not
CC detected in brain at 18 dpc, postnatal day 25 or postnatal day 55
CC (PubMed:16876275). {ECO:0000269|PubMed:10537154,
CC ECO:0000269|PubMed:10803597, ECO:0000269|PubMed:16876275}.
CC -!- DEVELOPMENTAL STAGE: In placenta, detected at 8 dpc, peaks at 12 dpc
CC and declines thereafter. {ECO:0000269|PubMed:10537154,
CC ECO:0000269|PubMed:10803597}.
CC -!- PTM: N-glycosylated and sialylated. {ECO:0000269|PubMed:10537154,
CC ECO:0000269|PubMed:10803597}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF128884; AAF71815.1; -; mRNA.
DR EMBL; AK145824; BAE26676.1; -; mRNA.
DR EMBL; CT030187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466672; EDL20564.1; -; Genomic_DNA.
DR EMBL; BC132514; AAI32515.1; -; mRNA.
DR EMBL; BC132516; AAI32517.1; -; mRNA.
DR EMBL; LM644170; CDW51417.1; -; mRNA.
DR CCDS; CCDS26242.1; -. [Q9JLV9-1]
DR CCDS; CCDS79164.1; -. [Q9JLV9-2]
DR RefSeq; NP_001298058.1; NM_001311129.1. [Q9JLV9-2]
DR RefSeq; NP_862900.1; NM_181852.2. [Q9JLV9-1]
DR AlphaFoldDB; Q9JLV9; -.
DR SMR; Q9JLV9; -.
DR STRING; 10090.ENSMUSP00000021778; -.
DR GlyGen; Q9JLV9; 1 site.
DR MaxQB; Q9JLV9; -.
DR PaxDb; Q9JLV9; -.
DR PRIDE; Q9JLV9; -.
DR ProteomicsDB; 289387; -. [Q9JLV9-1]
DR ProteomicsDB; 289388; -. [Q9JLV9-2]
DR DNASU; 107849; -.
DR Ensembl; ENSMUST00000021778; ENSMUSP00000021778; ENSMUSG00000055360. [Q9JLV9-1]
DR Ensembl; ENSMUST00000126540; ENSMUSP00000115024; ENSMUSG00000055360. [Q9JLV9-2]
DR GeneID; 107849; -.
DR KEGG; mmu:107849; -.
DR UCSC; uc007ply.1; mouse. [Q9JLV9-1]
DR UCSC; uc007plz.1; mouse.
DR CTD; 107849; -.
DR MGI; MGI:1858413; Prl2c5.
DR VEuPathDB; HostDB:ENSMUSG00000055360; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_0_1; -.
DR OMA; CLLEHAT; -.
DR OrthoDB; 1290070at2759; -.
DR PhylomeDB; Q9JLV9; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 107849; 1 hit in 37 CRISPR screens.
DR ChiTaRS; Prl2c5; mouse.
DR PRO; PR:Q9JLV9; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9JLV9; protein.
DR Bgee; ENSMUSG00000055360; Expressed in placenta and 9 other tissues.
DR ExpressionAtlas; Q9JLV9; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..222
FT /note="Prolactin-2C5"
FT /evidence="ECO:0000255"
FT /id="PRO_5008180054"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 33..40
FT /evidence="ECO:0000250|UniProtKB:P01236"
FT DISULFID 87..197
FT /evidence="ECO:0000250|UniProtKB:P01236"
FT DISULFID 214..222
FT /evidence="ECO:0000250|UniProtKB:P01236"
FT VAR_SEQ 2..11
FT /note="LPSLIQPCSW -> HSAFMDLCFLKRG (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_058802"
SQ SEQUENCE 222 AA; 25424 MW; 721E4EE1E71BF75C CRC64;
MLPSLIQPCS WILLLLLVNS SLLWKNVASL PMCAMRNDRC FMFFEDTFEL AGSLSHNISI
EVSELFTEFE KHYSNVPGLR DKSPMRCHTS FLPTPENKEQ ARHIRYEALL KSGDMILDAW
ENPLDYLVSE LSTIKNVPDI IISKATDIKK KINAVQNGVN ALMSTMNGDE ENKNPAWFLQ
SDNEDARIRS SYGMISCLDN DFKKVDIYLN ILKCYMLKID NC
