ID   ATG13_ASPFU             Reviewed;         958 AA.
AC   Q4WHN5;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Autophagy-related protein 13;
GN   Name=atg13; ORFNames=AFUA_2G04770;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Activates the atg1 kinase in a nutritional condition
CC       dependent manner through the TOR pathway, leading to autophagy. Also
CC       involved in cytoplasm to vacuole transport (Cvt) and more specifically
CC       in Cvt vesicle formation. Seems to play a role in the switching
CC       machinery regulating the conversion between the Cvt pathway and
CC       autophagy. Finally, atg13 is also required for glycogen storage during
CC       stationary phase (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with atg1 to form the atg1-atg13 kinase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06628}.
CC       Preautophagosomal structure {ECO:0000250|UniProtKB:Q06628}.
CC   -!- SIMILARITY: Belongs to the ATG13 family. Fungi subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAHF01000008; EAL87570.1; -; Genomic_DNA.
DR   RefSeq; XP_749608.1; XM_744515.1.
DR   AlphaFoldDB; Q4WHN5; -.
DR   SMR; Q4WHN5; -.
DR   STRING; 746128.CADAFUBP00002128; -.
DR   EnsemblFungi; EAL87570; EAL87570; AFUA_2G04770.
DR   GeneID; 3506687; -.
DR   KEGG; afm:AFUA_2G04770; -.
DR   eggNOG; KOG4573; Eukaryota.
DR   HOGENOM; CLU_007151_1_0_1; -.
DR   InParanoid; Q4WHN5; -.
DR   OMA; MHQHPRS; -.
DR   OrthoDB; 1519629at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0000423; P:mitophagy; IBA:GO_Central.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR   GO; GO:0034497; P:protein localization to phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.900.10; -; 1.
DR   InterPro; IPR040182; ATG13.
DR   InterPro; IPR018731; Atg13_N.
DR   InterPro; IPR036570; HORMA_dom_sf.
DR   PANTHER; PTHR13430; PTHR13430; 1.
DR   Pfam; PF10033; ATG13; 1.
PE   3: Inferred from homology;
KW   Autophagy; Cytoplasm; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..958
FT                   /note="Autophagy-related protein 13"
FT                   /id="PRO_0000157965"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          304..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          618..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          769..910
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          922..958
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..382
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..486
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        515..534
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..666
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        714..728
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        770..830
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        838..855
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   958 AA;  102702 MW;  E814C663AA166E6C CRC64;
     MHQHPRSPAP AAPTSSTRSN RSTDHRELDT DPSSPSSDVR MHNGRGLGIE PETEPSEQVQ
     RNTQPAKEAM AKLNQIITFN VEIEDTDILR EQLRIWRTCD AIENRPPPLI IETYLETKGL
     TNNQSLVILD ENGKRWDVLE ALTASGQASP VRPPHSNSDD VILERWRVEL GSASSKPPSD
     LGSILPTVYK KSIVLFRSLF TYSKFLPAWK FAKRNGRLRS NPALQIRYRI LDGRTASDRR
     QVDHLTVPLY EGNTKVVETY SFGVTDSPAG PFSVEVTYRT NCDFRVDDSE ALLSSRFMGA
     DDEIFRPSFP SRDANRRASN AEPGSAPLEK RTVEEPDPGR AYGSLSTFHH VGPATGASPI
     SALRAARESV TSSPSPPSSA SRRPLSAARA APTGRAAALA AEASPSPLRR PSISFQPFKA
     PPLSASPSLI DPPLGASPRS RPIVSAPSSE PKHMPPPSVA ASGRKTGQAA SENAIASSNS
     ASPRPAPIAR YSSAFSHRRG RPSSGGINKI EDDASSGKAS ATSSGAQPGS GLLAEVTGTS
     ADSLHADDEN ISEFLKMLDL RKDLLSPSNL SNLDAVARRT TVTSAALTRF QRMRDSNAAL
     SESMSSSLLL QRSSNASSKQ LSGVPPMVAG ASVSTASSPG KPISPHTPHT PAIPSRLSSN
     SIVDYNDHGH SDGRLLHGGP TSLPEDTTGE ETALVHRPPT VTAIDIPTSP RLFPPTYRRS
     SSAAQNRRSV VADEEEIFPF NMRSVSLGAE ERTNVSLSTL HRRHEYHNAA TNPEQQQESQ
     RASSSSDQGP TALPSPAKRE TRSQGDATVS GQTPELSSSA NHNLYQPRLG QFRSRGSFGG
     AHSLSSGSSS LARGGGIPTY LTERDNDRDG NASGSNSGNS TTEERRGFGR RVSAGRNYPP
     HPSQVEEDEP LLFAMSDFGA SRRSFEEGRQ GNHGADFGGS RRGSGRRGAG VPGFHVWS