ID   PR38A_DANRE             Reviewed;         313 AA.
AC   Q6DHU4; A7MCG8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Pre-mRNA-splicing factor 38A;
GN   Name=prpf38a; ORFNames=zgc:92059;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing as a component of the
CC       spliceosome. {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SUBUNIT: Component of the spliceosome B complex.
CC       {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SIMILARITY: Belongs to the PRP38 family. {ECO:0000305}.
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DR   EMBL; BC075873; AAH75873.1; -; mRNA.
DR   EMBL; BC152173; AAI52174.1; -; mRNA.
DR   RefSeq; NP_001003483.1; NM_001003483.2.
DR   AlphaFoldDB; Q6DHU4; -.
DR   SMR; Q6DHU4; -.
DR   STRING; 7955.ENSDARP00000057289; -.
DR   PaxDb; Q6DHU4; -.
DR   PRIDE; Q6DHU4; -.
DR   Ensembl; ENSDART00000057290; ENSDARP00000057289; ENSDARG00000039213.
DR   GeneID; 445089; -.
DR   KEGG; dre:445089; -.
DR   CTD; 84950; -.
DR   ZFIN; ZDB-GENE-040801-225; prpf38a.
DR   eggNOG; KOG2889; Eukaryota.
DR   GeneTree; ENSGT00730000111085; -.
DR   HOGENOM; CLU_039466_1_0_1; -.
DR   InParanoid; Q6DHU4; -.
DR   OMA; FYMRLVG; -.
DR   OrthoDB; 1182767at2759; -.
DR   PhylomeDB; Q6DHU4; -.
DR   TreeFam; TF105910; -.
DR   Reactome; R-DRE-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q6DHU4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000039213; Expressed in ovary and 29 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR005037; PRP38.
DR   InterPro; IPR024767; PRP38_C.
DR   PANTHER; PTHR23142; PTHR23142; 1.
DR   Pfam; PF03371; PRP38; 1.
DR   Pfam; PF12871; PRP38_assoc; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..313
FT                   /note="Pre-mRNA-splicing factor 38A"
FT                   /id="PRO_0000287276"
FT   REGION          1..179
FT                   /note="N-terminal protein interaction domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NAV1"
FT   REGION          182..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          172..201
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        188..204
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..227
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..248
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..313
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   313 AA;  37550 MW;  9E62E8AB515D5D73 CRC64;
     MANRTVKDAN SVHGTNPQYL VEKIIRTRIY ESKYWKEECF GLTAELVVDK AMELKFVGGV
     YGGNVKPTPF LCLTLKMLQI QPEKDIIVEF IKNEDFKYVR LLGAMYMRLT GTSVDCYKYL
     EPLYNDYRKI KSQNRNGEFE LMHVDEFIDE LLHAERMCDI ILPRLQKRQV LEEAELLDPR
     ISALEEDLDE VETSEEEDDE DEKPERMQSP EPHRRSYRDM DRPRRSPSPR YRRSRSPRRR
     SRSPKRRSPS PRRERDRDRH RSKSPRRHRS RSRERRHRSK SPGHHRSHRH RSHSKSPESR
     SKKSHKRSRR GNE