ID   PR38A_PONAB             Reviewed;         312 AA.
AC   Q5RDD2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Pre-mRNA-splicing factor 38A;
GN   Name=PRPF38A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing as a component of the
CC       spliceosome. {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SUBUNIT: Component of the spliceosome B complex. Interacts (via N-
CC       terminal interaction domain) with ZMAT2 AND MFAP1.
CC       {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SIMILARITY: Belongs to the PRP38 family. {ECO:0000305}.
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DR   EMBL; CR857982; CAH90225.1; -; mRNA.
DR   RefSeq; NP_001125092.1; NM_001131620.1.
DR   AlphaFoldDB; Q5RDD2; -.
DR   SMR; Q5RDD2; -.
DR   STRING; 9601.ENSPPYP00000001567; -.
DR   Ensembl; ENSPPYT00000001616; ENSPPYP00000001567; ENSPPYG00000001348.
DR   GeneID; 100171974; -.
DR   KEGG; pon:100171974; -.
DR   CTD; 84950; -.
DR   eggNOG; KOG2889; Eukaryota.
DR   GeneTree; ENSGT00730000111085; -.
DR   InParanoid; Q5RDD2; -.
DR   OrthoDB; 1182767at2759; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR005037; PRP38.
DR   InterPro; IPR024767; PRP38_C.
DR   PANTHER; PTHR23142; PTHR23142; 1.
DR   Pfam; PF03371; PRP38; 1.
DR   Pfam; PF12871; PRP38_assoc; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome; Spliceosome.
FT   CHAIN           1..312
FT                   /note="Pre-mRNA-splicing factor 38A"
FT                   /id="PRO_0000287275"
FT   REGION          1..179
FT                   /note="N-terminal protein interaction domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NAV1"
FT   REGION          181..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          170..204
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        188..204
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..227
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..312
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         11
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NAV1"
FT   MOD_RES         193
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NAV1"
FT   MOD_RES         194
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NAV1"
FT   MOD_RES         209
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NAV1"
FT   MOD_RES         226
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NAV1"
SQ   SEQUENCE   312 AA;  37477 MW;  0AABEEC0010EBD4B CRC64;
     MANRTVKDAH SIHGTNPQYL VEKIIRTRIY ESKYWKEECF GLTAELVVDK AMELRFVGGV
     YGGNIKPTPF LCLTLKMLQI QPEKDIIVEF IKNEDFKYVR MLGALYMRLT GTAIDCYKYL
     EPLYNDYRKI KSQNRNGEFE LMHVDEFIDE LLHSERVCDI ILPRLQKRYV LEEAEQLEPR
     VSALEEDMDD VESSEEEEEE DEKLERVPSP DHRRRSYRDL DKPRRSPTLR YRRSRSRSPR
     RRSRSPKRRS PSPRRERHRS KSPRRHRSRS RDRRHRSRSK SPGHHRSHRH RSHSKSPERS
     KKSHKKSRRG NE