ID   PR38A_XENLA             Reviewed;         312 AA.
AC   Q4FZQ6;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Pre-mRNA-splicing factor 38A;
GN   Name=prpf38a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing as a component of the
CC       spliceosome. {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SUBUNIT: Component of the spliceosome B complex.
CC       {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SIMILARITY: Belongs to the PRP38 family. {ECO:0000305}.
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DR   EMBL; BC099249; AAH99249.1; -; mRNA.
DR   RefSeq; NP_001085218.1; NM_001091749.1.
DR   AlphaFoldDB; Q4FZQ6; -.
DR   SMR; Q4FZQ6; -.
DR   DNASU; 432312; -.
DR   GeneID; 432312; -.
DR   KEGG; xla:432312; -.
DR   CTD; 432312; -.
DR   Xenbase; XB-GENE-980002; prpf38a.S.
DR   OrthoDB; 1182767at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 432312; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR005037; PRP38.
DR   InterPro; IPR024767; PRP38_C.
DR   PANTHER; PTHR23142; PTHR23142; 1.
DR   Pfam; PF03371; PRP38; 1.
DR   Pfam; PF12871; PRP38_assoc; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..312
FT                   /note="Pre-mRNA-splicing factor 38A"
FT                   /id="PRO_0000287277"
FT   REGION          1..179
FT                   /note="N-terminal protein interaction domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NAV1"
FT   REGION          180..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..203
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..226
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..312
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  37294 MW;  8FE21118FA5CEC7E CRC64;
     MANRTVKDAH SVHGTNPQYL VEKIIRTRIY ESKYWKEECF GLTAELVVDK AMELKFVGGV
     YGGNIKPTPF LCLTLKMLQI QPEKDIIVEF IKNEDFKYVR ALGALYMRLT GTATDCYKYL
     EPLYNDYRKV KVQNRDGEFE LMHVDEFIDQ LLHEERVCDV ILPRLQKRFV LEETEQLDPR
     VSALEEDMDD VESSEEEEDD DEKGRDPSPE HHRRNYRDLD RPRRSPSPRY RRSRSRSPRR
     RSRSPKRRSP SPPRRERHRS KSPRRHRSRS RERRHRSKSK SPGHHRSHRH RSHSKSPERS
     KKSHKKSRRG NE