ID   PR38A_XENTR             Reviewed;         312 AA.
AC   Q28H87;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Pre-mRNA-splicing factor 38A;
GN   Name=prpf38a; ORFNames=TEgg055l14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing as a component of the
CC       spliceosome. {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SUBUNIT: Component of the spliceosome B complex.
CC       {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NAV1}.
CC   -!- SIMILARITY: Belongs to the PRP38 family. {ECO:0000305}.
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DR   EMBL; CR760991; CAJ82119.1; -; mRNA.
DR   RefSeq; NP_001017140.1; NM_001017140.2.
DR   AlphaFoldDB; Q28H87; -.
DR   SMR; Q28H87; -.
DR   STRING; 8364.ENSXETP00000052923; -.
DR   PaxDb; Q28H87; -.
DR   Ensembl; ENSXETT00000052923; ENSXETP00000052923; ENSXETG00000008060.
DR   GeneID; 549894; -.
DR   KEGG; xtr:549894; -.
DR   CTD; 84950; -.
DR   Xenbase; XB-GENE-979997; prpf38a.
DR   eggNOG; KOG2889; Eukaryota.
DR   HOGENOM; CLU_039466_2_0_1; -.
DR   InParanoid; Q28H87; -.
DR   OMA; VELTYIG; -.
DR   OrthoDB; 1182767at2759; -.
DR   PhylomeDB; Q28H87; -.
DR   TreeFam; TF105910; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008060; Expressed in ovary and 13 other tissues.
DR   ExpressionAtlas; Q28H87; baseline.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR005037; PRP38.
DR   InterPro; IPR024767; PRP38_C.
DR   PANTHER; PTHR23142; PTHR23142; 1.
DR   Pfam; PF03371; PRP38; 1.
DR   Pfam; PF12871; PRP38_assoc; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..312
FT                   /note="Pre-mRNA-splicing factor 38A"
FT                   /id="PRO_0000287278"
FT   REGION          1..179
FT                   /note="N-terminal protein interaction domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NAV1"
FT   REGION          180..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..203
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..226
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..312
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  37353 MW;  94DD97FA2242C272 CRC64;
     MANRTVKDAH SVHGTNPQYL VEKIIRTRIY ESKYWKEECF GLTAELVVDK AMELKYVGGV
     YGGNIKPTPF LCLTLKMLQI QPEKDIIVEF IKNEDFKYVR TLGALYMRLT GTATDCYKYL
     EPLYNDYRKV KVQNRNGEFE LMHVDEFIDQ LLHEERVCDV ILPRLQKRFV LEETEQLDPR
     VSALEEDMDD VESSEEEEDE DEKGRDPSPE HHRRNYRDLD RPRRSPSPRY RRSRSRSPRR
     RSRSPKRRSP SPPRRERHRS KSPRRHRSRS RERRHRSKSK SPGHHRSHRH RSHSKSPERS
     KKSHKKSRRG NE