ID   PR38B_DANRE             Reviewed;         501 AA.
AC   Q6P7Y3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Pre-mRNA-splicing factor 38B;
GN   Name=prpf38b;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be required for pre-mRNA splicing. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PRP38 family. {ECO:0000305}.
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DR   EMBL; BC061448; AAH61448.1; -; mRNA.
DR   RefSeq; NP_998654.1; NM_213489.1.
DR   AlphaFoldDB; Q6P7Y3; -.
DR   SMR; Q6P7Y3; -.
DR   STRING; 7955.ENSDARP00000069565; -.
DR   PaxDb; Q6P7Y3; -.
DR   GeneID; 406810; -.
DR   KEGG; dre:406810; -.
DR   CTD; 55119; -.
DR   ZFIN; ZDB-GENE-040426-2878; prpf38b.
DR   eggNOG; KOG2888; Eukaryota.
DR   InParanoid; Q6P7Y3; -.
DR   OrthoDB; 1488857at2759; -.
DR   PRO; PR:Q6P7Y3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR005037; PRP38.
DR   PANTHER; PTHR23142; PTHR23142; 1.
DR   Pfam; PF03371; PRP38; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..501
FT                   /note="Pre-mRNA-splicing factor 38B"
FT                   /id="PRO_0000287238"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          208..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          281..302
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..223
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..271
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..330
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..406
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        407..432
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        433..451
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        452..467
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        468..490
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   501 AA;  59477 MW;  9C03ED612CE0C3DD CRC64;
     MAGSQQQQQQ QAVSKPTGGK HGNNLPLWGN EKTMNLNPMI LTNVLSSPYF KVQLYELKTY
     HEVVDEIYFK VNHVEPWEKG SRKTAGQTGM CGGVRGVGTG GIVSTAFCLL YKLFTLKLTR
     KQVMGLITHS DSPDIRALGF MYIRYTQPPP DLVDWYDEFL DDEEELDVKA GGGCVMTVGE
     MLRSFLTKLE WFSTLFPRIP VPVQKAIDQH MKSRPRKPPQ KDEQEEEEEE ATAAPAADTG
     RHGDKRRSRT PRRSPSPRKS QNRSRSRSHH RERHGASFDY ELERERDRQR KEREGKDRDR
     DRDRDRERDR ERDRDRRRSR TPDRNAERRR SRSRERRRSR STSRDKRTER KDRDKDREAE
     SERERSRKKD REHHKDRERS KDKRSKGEGE ERRHKDDKEE KKHREEKRSK RSRSRSRDRK
     HKAERSSKKR SRSGSRSRQE AGEEKNRKRE RSHSKDRQHK RSRSKERSHR RESSNERIHA
     RQERPSSESG ERTNSVRADS P