PR38B_RAT
ID PR38B_RAT Reviewed; 542 AA.
AC Q6AXY7;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Pre-mRNA-splicing factor 38B;
GN Name=Prpf38b;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5 AND SER-525, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: May be required for pre-mRNA splicing. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PRP38 family. {ECO:0000305}.
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DR EMBL; BC079264; AAH79264.1; -; mRNA.
DR RefSeq; NP_001019476.1; NM_001024305.2.
DR AlphaFoldDB; Q6AXY7; -.
DR STRING; 10116.ENSRNOP00000027738; -.
DR iPTMnet; Q6AXY7; -.
DR PhosphoSitePlus; Q6AXY7; -.
DR PaxDb; Q6AXY7; -.
DR PRIDE; Q6AXY7; -.
DR Ensembl; ENSRNOT00000027738; ENSRNOP00000027738; ENSRNOG00000020438.
DR GeneID; 499691; -.
DR KEGG; rno:499691; -.
DR UCSC; RGD:1562940; rat.
DR CTD; 55119; -.
DR RGD; 1562940; Prpf38b.
DR eggNOG; KOG2888; Eukaryota.
DR GeneTree; ENSGT00730000111085; -.
DR HOGENOM; CLU_034151_1_2_1; -.
DR InParanoid; Q6AXY7; -.
DR OMA; ERSHKHD; -.
DR OrthoDB; 1488857at2759; -.
DR TreeFam; TF313626; -.
DR PRO; PR:Q6AXY7; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000020438; Expressed in thymus and 20 other tissues.
DR Genevisible; Q6AXY7; RN.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR005037; PRP38.
DR PANTHER; PTHR23142; PTHR23142; 1.
DR Pfam; PF03371; PRP38; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; mRNA processing; mRNA splicing; Nucleus;
KW Phosphoprotein; Reference proteome; Spliceosome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT CHAIN 2..542
FT /note="Pre-mRNA-splicing factor 38B"
FT /id="PRO_0000287237"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 292..323
FT /evidence="ECO:0000255"
FT COMPBIAS 232..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..282
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..452
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT MOD_RES 5
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 227
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT MOD_RES 288
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT MOD_RES 290
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT MOD_RES 318
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT MOD_RES 320
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT MOD_RES 446
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT MOD_RES 471
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT MOD_RES 473
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT MOD_RES 479
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT MOD_RES 523
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
FT MOD_RES 525
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 530
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VTL8"
SQ SEQUENCE 542 AA; 63932 MW; 76165E893CA166C5 CRC64;
MANNSPALTG NSQPQHQAAA AVVQQQQQCG GGGATKPAVS GKQGNVLPLW GNEKTMNLNP
MILTNILSSP YFKVQLYELK TYHEVVDEIY FKVTHVEPWE KGSRKTAGQT GMCGGVRGVG
TGGIVSTAFC LLYKLFTLKL TRKQVMGLIT HTDSPYIRAL GFMYIRYTQP PTDLWDWFES
FLDDEEDLDV KAGGGCVMTI GEMLRSFLTK LEWFSTLFPR IPVPVQKNID QQIKTRPRKI
KKDGKEGVEE IDRHIERRRS RSPRRSLSPR RSPRRSRSRS HHRDGHGSSS FDRELEREKE
RQRLEREAKE REKERRRSRS LDRGLDRRRS RSRERHRSRS RSRDRKGDRR DRDREREKEN
ERGRRRDRDY DKDRGNDRER DRERSRERSK EQRSRGEGEE KKHKEDKEDR RHRDDKKESK
KKHSRSRSRE RKHRSRSRSR NAGKRSRSRS KDKASKHKNE SKEKSNKRSR SGSQGRTGSV
EKRKREHSPS REKSRKRSRS QDRSHKRDHD SKDQSDRQDH QRSQSVEPES QEKEHKNKDE
TV
