ID   PR3B1_MESAU             Reviewed;         221 AA.
AC   P14059;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Prolactin-3B1;
DE   AltName: Full=Chorionic somatomammotropin hormone 2;
DE   AltName: Full=Placental lactogen II;
DE            Short=PL-II;
DE   Flags: Precursor;
GN   Name=PRL3B1; Synonyms=CSH2;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2608054; DOI=10.1210/mend-3-11-1710;
RA   Southard J.N., Do L., Smith W.C., Tacamantes F.;
RT   "Hamster placental lactogen-II contains a structural feature unique among
RT   the growth hormone-prolactin-placental lactogen family.";
RL   Mol. Endocrinol. 3:1710-1713(1989).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M27146; AAA37088.1; -; mRNA.
DR   PIR; A41407; A41407.
DR   RefSeq; XP_005066493.1; XM_005066436.1.
DR   AlphaFoldDB; P14059; -.
DR   SMR; P14059; -.
DR   STRING; 10036.XP_005066493.1; -.
DR   GeneID; 101842847; -.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   OrthoDB; 1290070at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT   CHAIN           31..221
FT                   /note="Prolactin-3B1"
FT                   /id="PRO_0000032962"
FT   DISULFID        81..196
FT                   /evidence="ECO:0000250"
FT   DISULFID        213..221
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   221 AA;  25139 MW;  6A7A53E79425C518 CRC64;
     MQLPLTPLSF SGTLLLMAMS NFLLWEHVTS SASPRLSTRN LYQRVVELSH CTHDLASKVF
     TDFNMKFGKS ICRQKLMLYT CHTSSIPTPE NREQVHQTNS EDLLKVTISV LQAWEEPVKH
     MVAAVAALPG TSDAMLSRAK ELEERVLGLL EGLKIILNRI HPGAVENDYT FWSGWSDLQS
     SDEATRNIAF YTMGRCLRRD THKVDNYLKV LKCRDIHNNN C