ID   PR3B1_MOUSE             Reviewed;         222 AA.
AC   P09586;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Prolactin-3B1;
DE   AltName: Full=Chorionic somatomammotropin hormone 2;
DE   AltName: Full=Placental lactogen II;
DE            Short=PL-II;
DE   Flags: Precursor;
GN   Name=Prl3b1; Synonyms=Csh2, Pl-2, Pl2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3464966; DOI=10.1073/pnas.83.22.8496;
RA   Jackson L.L., Colosi P., Talamantes F., Linzer D.I.H.;
RT   "Molecular cloning of mouse placental lactogen cDNA.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:8496-8500(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1570305; DOI=10.1073/pnas.89.9.3864;
RA   Shida M.M., Jackson-Grusby L.L., Ross S.R., Linzer D.I.H.;
RT   "Placental-specific expression from the mouse placental lactogen II gene
RT   promoter.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:3864-3868(1992).
RN   [3]
RP   PROTEIN SEQUENCE OF 32-50.
RX   PubMed=3859868; DOI=10.1073/pnas.82.13.4356;
RA   Linzer D.I.H., Lee S.-J., Ogren L., Talamantes F., Nathans D.;
RT   "Identification of proliferin mRNA and protein in mouse placenta.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:4356-4359(1985).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Placental lactogen I is expressed in mid-
CC       pregnancy, while placental lactogen II is expressed throughout the
CC       later half of pregnancy.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M14647; AAA39947.1; -; mRNA.
DR   EMBL; M85066; AAA75165.1; -; Genomic_DNA.
DR   EMBL; M85062; AAA75165.1; JOINED; Genomic_DNA.
DR   EMBL; M85063; AAA75165.1; JOINED; Genomic_DNA.
DR   EMBL; M85064; AAA75165.1; JOINED; Genomic_DNA.
DR   CCDS; CCDS26393.1; -.
DR   PIR; A44090; A26489.
DR   RefSeq; NP_032891.1; NM_008865.3.
DR   AlphaFoldDB; P09586; -.
DR   SMR; P09586; -.
DR   STRING; 10090.ENSMUSP00000047680; -.
DR   PaxDb; P09586; -.
DR   PeptideAtlas; P09586; -.
DR   PRIDE; P09586; -.
DR   DNASU; 18776; -.
DR   Ensembl; ENSMUST00000035273; ENSMUSP00000047680; ENSMUSG00000038891.
DR   GeneID; 18776; -.
DR   KEGG; mmu:18776; -.
DR   UCSC; uc007pxi.1; mouse.
DR   CTD; 18776; -.
DR   MGI; MGI:97607; Prl3b1.
DR   VEuPathDB; HostDB:ENSMUSG00000038891; -.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   GeneTree; ENSGT00950000182818; -.
DR   HOGENOM; CLU_088274_0_1_1; -.
DR   InParanoid; P09586; -.
DR   OMA; SHYTHDL; -.
DR   OrthoDB; 1290070at2759; -.
DR   PhylomeDB; P09586; -.
DR   TreeFam; TF332592; -.
DR   BioGRID-ORCS; 18776; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Prl3b1; mouse.
DR   PRO; PR:P09586; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; P09586; protein.
DR   Bgee; ENSMUSG00000038891; Expressed in placenta labyrinth and 62 other tissues.
DR   ExpressionAtlas; P09586; baseline and differential.
DR   Genevisible; P09586; MM.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000269|PubMed:3859868"
FT   CHAIN           32..222
FT                   /note="Prolactin-3B1"
FT                   /id="PRO_0000032961"
FT   DISULFID        82..197
FT                   /evidence="ECO:0000250"
FT   DISULFID        214..222
FT                   /evidence="ECO:0000250"
FT   CONFLICT        101..160
FT                   /note="Missing (in Ref. 2; AAA75165)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   222 AA;  25159 MW;  5A0D19D03D76EB05 CRC64;
     MKLSLSQPCS FSGALLLLAV SNLLVWEKVT SLPNYRLPTE SLYQRVIVVS HNAHDLASKA
     FMEFEMKFGR TAWTYGLMLS PCHTAAILTP ENSEQVHQTT SEDLLKVSIT ILQAWEEPLK
     HMVAAVAALP HVPDTLLSRT KELEERIQGL LEGLKIIFNR VYPGAVASDY TFWSAWSDLQ
     SSDESTKNSA LRTLWRCVRR DTHKVDNYLK VLKCRDVHNN NC