ID   PR3B1_RAT               Reviewed;         221 AA.
AC   P09321; O70245; Q4QRC3;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   25-MAY-2022, entry version 139.
DE   RecName: Full=Prolactin-3B1;
DE   AltName: Full=Chorionic somatomammotropin hormone 2;
DE   AltName: Full=Placental lactogen II;
DE            Short=PL-II;
DE   AltName: Full=RPLII;
DE   Flags: Precursor;
GN   Name=Prl3b1; Synonyms=Csh2, Pl2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2874144; DOI=10.1016/s0021-9258(18)67468-x;
RA   Duckworth M.L., Kirk K.L., Friesen H.G.;
RT   "Isolation and identification of a cDNA clone of rat placental lactogen
RT   II.";
RL   J. Biol. Chem. 261:10871-10878(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=9492027; DOI=10.1210/endo.139.3.5838;
RA   Shah P., Sun Y., Szpirer C., Duckworth M.L.;
RT   "Rat placental lactogen II gene: characterization of gene structure and
RT   placental-specific expression.";
RL   Endocrinology 139:967-973(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Placental lactogen II is expressed from days 12 to
CC       term of pregnancy.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M13749; AAA41887.1; -; mRNA.
DR   EMBL; AF026298; AAC06277.1; -; Genomic_DNA.
DR   EMBL; AF026294; AAC06277.1; JOINED; Genomic_DNA.
DR   EMBL; AF026295; AAC06277.1; JOINED; Genomic_DNA.
DR   EMBL; AF026297; AAC06277.1; JOINED; Genomic_DNA.
DR   EMBL; BC097255; AAH97255.1; -; mRNA.
DR   PIR; A25951; A25951.
DR   RefSeq; NP_036667.1; NM_012535.3.
DR   AlphaFoldDB; P09321; -.
DR   SMR; P09321; -.
DR   STRING; 10116.ENSRNOP00000023086; -.
DR   ChEMBL; CHEMBL2176810; -.
DR   PaxDb; P09321; -.
DR   Ensembl; ENSRNOT00000023086; ENSRNOP00000023086; ENSRNOG00000017185.
DR   GeneID; 24283; -.
DR   KEGG; rno:24283; -.
DR   UCSC; RGD:2429; rat.
DR   CTD; 18776; -.
DR   RGD; 2429; Prl3b1.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   GeneTree; ENSGT00950000182818; -.
DR   HOGENOM; CLU_088274_0_1_1; -.
DR   InParanoid; P09321; -.
DR   OMA; SHYTHDL; -.
DR   OrthoDB; 1290070at2759; -.
DR   PhylomeDB; P09321; -.
DR   TreeFam; TF332592; -.
DR   PRO; PR:P09321; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   ExpressionAtlas; P09321; baseline and differential.
DR   Genevisible; P09321; RN.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000250"
FT   CHAIN           31..221
FT                   /note="Prolactin-3B1"
FT                   /id="PRO_0000032965"
FT   DISULFID        81..196
FT                   /evidence="ECO:0000250"
FT   DISULFID        213..221
FT                   /evidence="ECO:0000250"
FT   CONFLICT        1
FT                   /note="M -> V (in Ref. 1; AAA41887)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   221 AA;  25007 MW;  36F23B647705DDF7 CRC64;
     MQLSLTQPCF SGTLLMLAVS TLLLWEQVTS APNYRMSTGS LYQRVVELSH YTHDLASKVF
     IEFDMKFGRT VWTHNLMLSP CHTAAIPTPE NSEQVHQAKS EDLLKVSITI LQAWQEPLKH
     IVAAVATLPD GSDTLLSRTK ELEERIQGLL EGLETILSRV QPGAVGSDYT FWSEWSDLQS
     SDKSTKNGVL SVLYRCMRRD THKVDNFLKV LKCRDIYNNN C