PR3C1_MOUSE
ID PR3C1_MOUSE Reviewed; 212 AA.
AC Q9QUN5; Q5SZY4;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Prolactin-3C1;
DE AltName: Full=Decidualin;
DE AltName: Full=Placental prolactin-like protein J;
DE Short=PLP-J;
DE Short=PRL-like protein J;
DE AltName: Full=Prolactin-like protein I;
DE Short=PLP-I;
DE Short=PRL-like protein I;
DE Flags: Precursor;
GN Name=Prl3c1; Synonyms=Prlpi, Prlpj;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=10542329; DOI=10.1016/s0167-4781(99)00160-8;
RA Hiraoka Y., Ogawa M., Sakai Y., Takeuchi Y., Komatsu N., Shiozawa M.,
RA Tanabe K., Aiso S.;
RT "PLP-I: a novel prolactin-like gene in rodents.";
RL Biochim. Biophys. Acta 1447:291-297(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10537137; DOI=10.1210/endo.140.11.7138;
RA Toft D.J., Linzer D.I.;
RT "Prolactin (PRL)-like protein J, a novel member of the PRL/growth hormone
RT family, is exclusively expressed in maternal decidua.";
RL Endocrinology 140:5095-5101(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10856884; DOI=10.1677/joe.0.1660063;
RA Dai G., Wang D., Liu B., Kasik J.W., Mueller H., White R.A., Hummel G.S.,
RA Soares M.J.;
RT "Three novel paralogs of the rodent prolactin gene family.";
RL J. Endocrinol. 166:63-75(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in decidua.
CC {ECO:0000269|PubMed:10537137}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI24361.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB019118; BAA85988.1; -; mRNA.
DR EMBL; AF150740; AAF13035.1; -; mRNA.
DR EMBL; AF234637; AAF40436.1; -; mRNA.
DR EMBL; AL589679; CAI24360.1; -; Genomic_DNA.
DR EMBL; AL589679; CAI24361.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS26392.1; -.
DR RefSeq; NP_001156690.1; NM_001163218.1.
DR RefSeq; NP_038794.1; NM_013766.2.
DR AlphaFoldDB; Q9QUN5; -.
DR SMR; Q9QUN5; -.
DR STRING; 10090.ENSMUSP00000018066; -.
DR GlyGen; Q9QUN5; 1 site.
DR PhosphoSitePlus; Q9QUN5; -.
DR MaxQB; Q9QUN5; -.
DR PaxDb; Q9QUN5; -.
DR PRIDE; Q9QUN5; -.
DR DNASU; 27372; -.
DR Ensembl; ENSMUST00000018066; ENSMUSP00000018066; ENSMUSG00000017922.
DR GeneID; 27372; -.
DR KEGG; mmu:27372; -.
DR UCSC; uc007pxh.3; mouse.
DR CTD; 27372; -.
DR MGI; MGI:1351649; Prl3c1.
DR VEuPathDB; HostDB:ENSMUSG00000017922; -.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; Q9QUN5; -.
DR OMA; CMILWIS; -.
DR OrthoDB; 1290070at2759; -.
DR PhylomeDB; Q9QUN5; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 27372; 3 hits in 70 CRISPR screens.
DR ChiTaRS; Prl3a1; mouse.
DR PRO; PR:Q9QUN5; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9QUN5; protein.
DR Bgee; ENSMUSG00000017922; Expressed in gastrula and 13 other tissues.
DR ExpressionAtlas; Q9QUN5; baseline and differential.
DR Genevisible; Q9QUN5; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..212
FT /note="Prolactin-3C1"
FT /id="PRO_0000045276"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 80..188
FT /evidence="ECO:0000250"
SQ SEQUENCE 212 AA; 24706 MW; 651787B7861A6392 CRC64;
MQLSLTQART WKGLFLLVSC MFLWVYVTAT RYDRKSNEEI YDNLLSSSRH IHRVAKKMYK
ILDSKLTEGV CFRNKNTKMC QTISTHSVKK NEDLLKVIIN VSNFWTYPLK MLIPAVLTHL
DSDDGMMTRA VELNYGNKVV LEGAKALLSR IQPGIEENNE PDRWSDLREL RSSKKSKHLL
AFCKFFYCLR KDTKMVTCYL RALKHGKIKT IC
