ID   PR3C1_RAT               Reviewed;         211 AA.
AC   Q9QUL0; Q9R0S7;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Prolactin-3C1;
DE   AltName: Full=Decidualin;
DE   AltName: Full=Placental prolactin-like protein J;
DE            Short=PLP-J;
DE            Short=PRL-like protein J;
DE   AltName: Full=Prolactin-like protein I;
DE            Short=PLP-I;
DE            Short=PRL-like protein I;
DE   Flags: Precursor;
GN   Name=Prl3c1; Synonyms=Prlpi, Prlpj;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10471365; DOI=10.1006/bbrc.1999.1260;
RA   Ishibashi K., Imai M.;
RT   "Identification of four members of the rat prolactin/growth hormone gene
RT   family.";
RL   Biochem. Biophys. Res. Commun. 262:575-578(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=10542329; DOI=10.1016/s0167-4781(99)00160-8;
RA   Hiraoka Y., Ogawa M., Sakai Y., Takeuchi Y., Komatsu N., Shiozawa M.,
RA   Tanabe K., Aiso S.;
RT   "PLP-I: a novel prolactin-like gene in rodents.";
RL   Biochim. Biophys. Acta 1447:291-297(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=10537137; DOI=10.1210/endo.140.11.7138;
RA   Toft D.J., Linzer D.I.;
RT   "Prolactin (PRL)-like protein J, a novel member of the PRL/growth hormone
RT   family, is exclusively expressed in maternal decidua.";
RL   Endocrinology 140:5095-5101(1999).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=10856884; DOI=10.1677/joe.0.1660063;
RA   Dai G., Wang D., Liu B., Kasik J.W., Mueller H., White R.A., Hummel G.S.,
RA   Soares M.J.;
RT   "Three novel paralogs of the rodent prolactin gene family.";
RL   J. Endocrinol. 166:63-75(2000).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in decidual tissue.
CC       {ECO:0000269|PubMed:10537137, ECO:0000269|PubMed:10856884}.
CC   -!- DEVELOPMENTAL STAGE: Expression limited to early pregnancy with
CC       abundant expression on day 7, slightly declining expression on day 9,
CC       and no detectable expression by day 11. {ECO:0000269|PubMed:10537137}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB019945; BAA83729.1; -; mRNA.
DR   EMBL; AB019119; BAA85989.1; -; mRNA.
DR   EMBL; AF150741; AAF13036.1; -; mRNA.
DR   EMBL; AF234638; AAF40437.1; -; mRNA.
DR   RefSeq; NP_112606.1; NM_031316.1.
DR   AlphaFoldDB; Q9QUL0; -.
DR   SMR; Q9QUL0; -.
DR   STRING; 10116.ENSRNOP00000023166; -.
DR   GlyGen; Q9QUL0; 2 sites.
DR   iPTMnet; Q9QUL0; -.
DR   PhosphoSitePlus; Q9QUL0; -.
DR   PaxDb; Q9QUL0; -.
DR   GeneID; 58937; -.
DR   KEGG; rno:58937; -.
DR   UCSC; RGD:69341; rat.
DR   CTD; 27372; -.
DR   RGD; 69341; Prl3c1.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   HOGENOM; CLU_088274_0_1_1; -.
DR   InParanoid; Q9QUL0; -.
DR   OMA; CMILWIS; -.
DR   OrthoDB; 1290070at2759; -.
DR   PhylomeDB; Q9QUL0; -.
DR   TreeFam; TF332592; -.
DR   PRO; PR:Q9QUL0; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Bgee; ENSRNOG00000017203; Expressed in testis.
DR   ExpressionAtlas; Q9QUL0; baseline and differential.
DR   Genevisible; Q9QUL0; RN.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..211
FT                   /note="Prolactin-3C1"
FT                   /id="PRO_0000045277"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        80..187
FT                   /evidence="ECO:0000250"
FT   CONFLICT        91
FT                   /note="N -> H (in Ref. 1; BAA83729 and 4; AAF40437)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   211 AA;  24575 MW;  8F56B7386D9F276E CRC64;
     MQLSLTQART WKGLLLLVSC MILWISVTPT PYDQMSNEEL YDNLLSCSHR THVVARKMYK
     ILDLNVAERR CFKNKRNNTC HTTSTHTAKT NEDLLKVIIS VSNAWIYPLK MLIPAVLTHL
     GSYDGMMARA IELNYGNQKI LEGAKFLLSR IQPGIEENDY PVWSSLKELR SSNKSIHLFA
     FCKFFYCLRK DTKKIKDYLQ ILRPNIIKNK W