ID   PR3CB_DANRE             Reviewed;         317 AA.
AC   Q6P950;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 3C-B;
GN   Name=ppp1r3cb; ORFNames=zgc:73259;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH60926.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Retina {ECO:0000312|EMBL:AAH60926.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a glycogen-targeting subunit for PP1 and regulates
CC       its activity. Activates glycogen synthase, reduces glycogen
CC       phosphorylase activity and limits glycogen breakdown (By similarity).
CC       {ECO:0000250|UniProtKB:Q7TMB3}.
CC   -!- SUBUNIT: Interacts with PPP1CC catalytic subunit of PP1 and associates
CC       with glycogen. Forms complexes with glycogen phosphorylase, glycogen
CC       synthase and phosphorylase kinase which is necessary for its regulation
CC       of PP1 activity (By similarity). {ECO:0000250|UniProtKB:Q7TMB3}.
CC   -!- DOMAIN: The N-terminal region is required for binding to PP1, the
CC       central region is required for binding to glycogen and the C-terminal
CC       region is required for binding to glycogen phosphorylase, glycogen
CC       synthase and phosphorylase kinase. {ECO:0000250|UniProtKB:Q7TMB3}.
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DR   EMBL; BC060926; AAH60926.1; -; mRNA.
DR   RefSeq; NP_957128.1; NM_200834.1.
DR   AlphaFoldDB; Q6P950; -.
DR   SMR; Q6P950; -.
DR   STRING; 7955.ENSDARP00000014980; -.
DR   CAZy; CBM21; Carbohydrate-Binding Module Family 21.
DR   PaxDb; Q6P950; -.
DR   GeneID; 393807; -.
DR   KEGG; dre:393807; -.
DR   CTD; 393807; -.
DR   ZFIN; ZDB-GENE-040426-1733; ppp1r3cb.
DR   eggNOG; KOG3986; Eukaryota.
DR   InParanoid; Q6P950; -.
DR   OrthoDB; 1232750at2759; -.
DR   PhylomeDB; Q6P950; -.
DR   Reactome; R-DRE-3322077; Glycogen synthesis.
DR   PRO; PR:Q6P950; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR   GO; GO:2001069; F:glycogen binding; IBA:GO_Central.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR   GO; GO:0019903; F:protein phosphatase binding; ISS:UniProtKB.
DR   GO; GO:0005978; P:glycogen biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0005977; P:glycogen metabolic process; ISS:UniProtKB.
DR   GO; GO:0005979; P:regulation of glycogen biosynthetic process; IBA:GO_Central.
DR   Gene3D; 2.60.40.2440; -; 1.
DR   InterPro; IPR005036; CBM21_dom.
DR   InterPro; IPR038175; CBM21_dom_sf.
DR   InterPro; IPR017434; Pase-1_reg-su_3B/C/D_met.
DR   InterPro; IPR030683; PP1_3C.
DR   PANTHER; PTHR12307:SF15; PTHR12307:SF15; 1.
DR   Pfam; PF03370; CBM_21; 1.
DR   PIRSF; PIRSF038207; PP1_GT_animal; 1.
DR   PIRSF; PIRSF500813; PP1_PTG; 1.
DR   PROSITE; PS51159; CBM21; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Glycogen metabolism; Reference proteome.
FT   CHAIN           1..317
FT                   /note="Protein phosphatase 1 regulatory subunit 3C-B"
FT                   /id="PRO_0000285930"
FT   DOMAIN          150..258
FT                   /note="CBM21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00491"
SQ   SEQUENCE   317 AA;  36323 MW;  D1B814D0BD13C43E CRC64;
     MNCTRVLQIL NPRPMPSPIM PVDVAMRICL AHSPPLRSFL SSYEDCKSRN LVNQYKPLRS
     CISSKTEDDT ANITWKSPET KAKKKVVFAD SKGMSLTAVH VFKEFEEDLM LDLQFELSDL
     EDAIVGLKAE KEKNFSLGFP QPAADYLDFR NRLKKNLVCL ENCIIQERSV TGTVKVSNVS
     FEKVVHVRIT FDSWKSHTDI PCTYMNNVYG CEDVDTFSFS IDLPSFVAPH EQVEFCLSYK
     THDMTYWDNN DGKNYKLVHT ENDSSQASVI QNATTDFKAQ GKRPDMEFDQ FGSPRTSSGF
     FPEWQSWGHI ENNTPYW