PR3D1_MOUSE
ID PR3D1_MOUSE Reviewed; 224 AA.
AC P18121;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Prolactin-3D1;
DE AltName: Full=Chorionic somatomammotropin hormone 1;
DE AltName: Full=Placental lactogen I;
DE Short=PL-I;
DE Flags: Precursor;
GN Name=Prl3d1; Synonyms=Csh1, Pl-1, Pl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3153461; DOI=10.1210/mend-1-11-767;
RA Colosi P., Talamantes F., Linzer D.I.H.;
RT "Molecular cloning and expression of mouse placental lactogen I
RT complementary deoxyribonucleic acid.";
RL Mol. Endocrinol. 1:767-776(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.
RC STRAIN=BALB/cJ;
RX PubMed=8469232; DOI=10.1210/mend.7.2.8469232;
RA Shida M.M., Ng Y.K., Soares M.J., Linzer D.I.H.;
RT "Trophoblast-specific transcription from the mouse placental lactogen-I
RT gene promoter.";
RL Mol. Endocrinol. 7:181-188(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-224.
RC STRAIN=C57BL/6J;
RX PubMed=8043949; DOI=10.1007/bf00356553;
RA Ko M.S., Wang X., Horton J.H., Hagen M.D., Takahashi N., Maezaki Y.,
RA Nadeau J.H.;
RT "Genetic mapping of 40 cDNA clones on the mouse genome by PCR.";
RL Mamm. Genome 5:349-355(1994).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- DEVELOPMENTAL STAGE: Placental lactogen I is expressed in mid-
CC pregnancy, while placental lactogen II is expressed throughout the
CC later half of pregnancy.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; M35662; AAA39404.1; -; mRNA.
DR EMBL; S58124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U05734; AAB60475.1; -; Genomic_DNA.
DR CCDS; CCDS56874.1; -.
DR PIR; A40062; A40062.
DR AlphaFoldDB; P18121; -.
DR SMR; P18121; -.
DR STRING; 10090.ENSMUSP00000080731; -.
DR GlyGen; P18121; 2 sites.
DR iPTMnet; P18121; -.
DR PhosphoSitePlus; P18121; -.
DR PaxDb; P18121; -.
DR PRIDE; P18121; -.
DR MGI; MGI:97606; Prl3d1.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR InParanoid; P18121; -.
DR PhylomeDB; P18121; -.
DR ChiTaRS; Prl3d1; mouse.
DR PRO; PR:P18121; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P18121; protein.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000250"
FT CHAIN 30..224
FT /note="Prolactin-3D1"
FT /id="PRO_0000032960"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 81..199
FT /evidence="ECO:0000250"
FT DISULFID 216..224
FT /evidence="ECO:0000250"
SQ SEQUENCE 224 AA; 25524 MW; 0B0907D37CC3732B CRC64;
MQLTLNLSGS AGMQLLLLVS SLLLWENVSS KPTAMVPTED LYTRLAELLH NTFILAADVY
REFDLDFFDK TWITDRTLPL CHTASIHTPE NREEVHETKT EDLLKAMINV SISWKEPLKH
LVSALTALPG ASESMGKKAA DIKGRNLVIL EGLQTIYNRS QANIEENENF DYPAWSGLEE
LQSPNEDTHL FAVYNLCRCI KRDIHKIDSY IKVLRCRVVF QNEC
