ID   PR3D1_RAT               Reviewed;         230 AA.
AC   P21702;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Prolactin-3D1;
DE   AltName: Full=Chorionic somatomammotropin hormone 1;
DE   AltName: Full=Placental lactogen I;
DE            Short=PL-I;
DE   Flags: Precursor;
GN   Name=Prl3d1; Synonyms=Csh1, Pl1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2373051; DOI=10.1210/endo-127-2-702;
RA   Robertson M.C., Croze F., Schroedter I.C., Friesen H.G.;
RT   "Molecular cloning and expression of rat placental lactogen-I complementary
RT   deoxyribonucleic acid.";
RL   Endocrinology 127:702-710(1990).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Placental lactogen I is expressed in mid-
CC       pregnancy, while placental lactogen II is expressed throughout the
CC       later half of pregnancy.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M55269; AAA41506.1; -; mRNA.
DR   PIR; A37399; A37399.
DR   AlphaFoldDB; P21702; -.
DR   SMR; P21702; -.
DR   STRING; 10116.ENSRNOP00000049253; -.
DR   GlyGen; P21702; 2 sites.
DR   UCSC; RGD:2427; rat.
DR   RGD; 2427; Prl3d1.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   InParanoid; P21702; -.
DR   PhylomeDB; P21702; -.
DR   PRO; PR:P21702; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000250"
FT   CHAIN           30..230
FT                   /note="Prolactin-3D1"
FT                   /id="PRO_0000032963"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        158
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        81..200
FT                   /evidence="ECO:0000250"
FT   DISULFID        217..225
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   230 AA;  26324 MW;  95B9669F713192BE CRC64;
     MQLTLTLSRA SGMQLFLLVS SLLLWEKVAS KPTAIVSTDD LYHCLVEQSH NTFIMAADVY
     REFDINFAKR SWMKDRILPL CHTASIHTPE NLEEVHEMKT EDFLNSIINV SVSWKEPLKH
     LVVCSDCSSG ASVSMGKKAV DMKDKNLIIL EGLQTLYNRT QAKVEENFEN FDYPAWSGLK
     DLDSSDEEHH LFAICNLCRC VKRDIHKIDT YLKVLRCRVV FKNECGVSTF