PR3D4_RAT
ID PR3D4_RAT Reviewed; 223 AA.
AC P34207; Q4QRA7;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Prolactin-3D4;
DE AltName: Full=Chorionic somatomammotropin hormone 1 variant;
DE AltName: Full=Placental lactogen I variant;
DE Short=PL-IV;
DE Flags: Precursor;
GN Name=Prl3d4; Synonyms=Csh1v;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Placenta;
RA Dai G., Deb S., Soares M.J.;
RL Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 29-73.
RC TISSUE=Placenta;
RX PubMed=1988439; DOI=10.1016/s0021-9258(18)52337-1;
RA Deb S., Faria T.N., Roby K.F., Larsen D., Kwok S.C.M., Talamantes F.,
RA Soares M.J.;
RT "Identification and characterization of a new member of the prolactin
RT family, placental lactogen-I variant.";
RL J. Biol. Chem. 266:1605-1610(1991).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- DEVELOPMENTAL STAGE: Predominantly synthesized during the later stage
CC of gestation.
CC -!- PTM: N-glycosylated.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; U32679; AAC52427.1; -; mRNA.
DR EMBL; BC097302; AAH97302.1; -; mRNA.
DR PIR; A38666; A38666.
DR PIR; A49160; A49160.
DR RefSeq; NP_150236.1; NM_033233.1.
DR RefSeq; XP_008769896.1; XM_008771674.2.
DR AlphaFoldDB; P34207; -.
DR SMR; P34207; -.
DR STRING; 10116.ENSRNOP00000022512; -.
DR GlyGen; P34207; 2 sites.
DR PaxDb; P34207; -.
DR Ensembl; ENSRNOT00000082821; ENSRNOP00000068935; ENSRNOG00000016792.
DR GeneID; 24282; -.
DR KEGG; rno:24282; -.
DR UCSC; RGD:2428; rat.
DR CTD; 24282; -.
DR RGD; 2428; Prl3d4.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR InParanoid; P34207; -.
DR OMA; CHTSNIV; -.
DR OrthoDB; 1290070at2759; -.
DR PhylomeDB; P34207; -.
DR TreeFam; TF332592; -.
DR PRO; PR:P34207; -.
DR Proteomes; UP000002494; Chromosome 17.
DR ExpressionAtlas; P34207; baseline.
DR Genevisible; P34207; RN.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IMP:RGD.
DR GO; GO:0042976; P:activation of Janus kinase activity; IMP:RGD.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000269|PubMed:1988439"
FT CHAIN 29..223
FT /note="Prolactin-3D4"
FT /id="PRO_0000032964"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 80..198
FT /evidence="ECO:0000250"
FT DISULFID 215..223
FT /evidence="ECO:0000250"
SQ SEQUENCE 223 AA; 25844 MW; 09EAC606BC227912 CRC64;
MQLTLTLSGS SMQLLLLVSN LLLWENMASK PTVLVSTEDL YHRLVEQSHN TFIKAADVYR
EFDINFAKRS WMKDRILPLC HTASIHVPEN REEVHEIKTE DLLRSIINIS VSWKEPLKHF
VSAVTDLPGA SASMRKKAVD MKDKNLIILE GLQKIFNRTQ TKVEENENFD YPAWSGLKDL
QSSDEDTHLF AIYNLCRCFK SDIHKIDTYL KVLRCRVVFK NEC
