PR46B_CHLRE
ID PR46B_CHLRE Reviewed; 267 AA.
AC Q94EY1;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Coiled-coil domain-containing protein 103 homolog;
DE AltName: Full=Protein PR46bp;
GN Name=PR46b; ORFNames=CHLREDRAFT_24002;
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CC-620;
RX PubMed=11805055; DOI=10.1093/genetics/160.1.181;
RA Ferris P.J., Armbrust E.V., Goodenough U.W.;
RT "Genetic structure of the mating-type locus of Chlamydomonas reinhardtii.";
RL Genetics 160:181-200(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CC-503;
RA Ferris P., Olson B.J., De Hoff P.L., Douglass S., Casero D., Prochnik S.,
RA Geng S., Rai R., Grimwood J., Schmutz J., Nishii I., Hamaji T., Nozaki H.,
RA Pellegrini M., Umen J.G.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [4]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=22581229; DOI=10.1038/ng.2277;
RA Panizzi J.R., Becker-Heck A., Castleman V.H., Al-Mutairi D.A., Liu Y.,
RA Loges N.T., Pathak N., Austin-Tse C., Sheridan E., Schmidts M., Olbrich H.,
RA Werner C., Haffner K., Hellman N., Chodhari R., Gupta A., Kramer-Zucker A.,
RA Olale F., Burdine R.D., Schier A.F., O'Callaghan C., Chung E.M.,
RA Reinhardt R., Mitchison H.M., King S.M., Omran H., Drummond I.A.;
RT "CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly
RT of ciliary dynein arms.";
RL Nat. Genet. 44:714-719(2012).
CC -!- FUNCTION: Dynein-attachment factor required for cilia motility.
CC {ECO:0000269|PubMed:22581229}.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:22581229}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22581229}. Cell
CC projection, cilium, flagellum {ECO:0000269|PubMed:22581229}.
CC -!- SIMILARITY: Belongs to the CCDC103/PR46b family. {ECO:0000305}.
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DR EMBL; AF387366; AAK70875.1; -; Genomic_DNA.
DR EMBL; GU814014; ADF43150.1; -; Genomic_DNA.
DR EMBL; DS496110; EDP08368.1; -; Genomic_DNA.
DR RefSeq; XP_001696391.1; XM_001696339.1.
DR AlphaFoldDB; Q94EY1; -.
DR SMR; Q94EY1; -.
DR STRING; 3055.EDP08368; -.
DR PaxDb; Q94EY1; -.
DR PRIDE; Q94EY1; -.
DR GeneID; 5722152; -.
DR KEGG; cre:CHLRE_06g253404v5; -.
DR eggNOG; ENOG502S3J2; Eukaryota.
DR HOGENOM; CLU_1043332_0_0_1; -.
DR InParanoid; Q94EY1; -.
DR OrthoDB; 1451158at2759; -.
DR GO; GO:0005858; C:axonemal dynein complex; IDA:BHF-UCL.
DR GO; GO:0005930; C:axoneme; IDA:BHF-UCL.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0036157; C:outer dynein arm; IDA:BHF-UCL.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
DR GO; GO:0070286; P:axonemal dynein complex assembly; IEA:InterPro.
DR InterPro; IPR042422; CC103.
DR InterPro; IPR031733; Dynein_attach_N.
DR InterPro; IPR025986; RPAP3-like_C.
DR PANTHER; PTHR28572; PTHR28572; 1.
DR Pfam; PF15867; Dynein_attach_N; 1.
DR Pfam; PF13877; RPAP3_C; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW Flagellum.
FT CHAIN 1..267
FT /note="Coiled-coil domain-containing protein 103 homolog"
FT /id="PRO_0000419464"
FT REGION 86..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 267 AA; 28727 MW; 2845DFF231724F45 CRC64;
MSSTPDHRPS KVSKELANAA CDDFKRKAID EAKKRAVAQR VDYDTFKNMV LTAHLKPITA
PKQLNNDRPL PCWSFGVDGK MLKEQISQSQ LPPTTPTEVP TTSGDFTRDW RRNCPTPDDK
YRYLKLCGPE GLQAVFRVEI SAEVLREMLA VLEACWLGHG GVAEEAEGGA GAALLEAAFV
VQVLEAVSTA GRFSLTVKLL GSSAKPTLER LFSGLQSAVL ASQAAHQGKQ EQPAAAEAPH
EEGGSTVDPC SPTRVAALQA MYGLPPS
