PR4A1_MOUSE
ID PR4A1_MOUSE Reviewed; 227 AA.
AC O35256;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Prolactin-4A1;
DE AltName: Full=Placental prolactin-like protein A;
DE Short=PLP-A;
DE Short=PRL-like protein A;
DE Flags: Precursor;
GN Name=Prl4a1; Synonyms=Prlpa;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J;
RX PubMed=9389542; DOI=10.1210/endo.138.12.5626;
RA Lin J., Poole J., Linzer D.I.;
RT "Three new members of the mouse prolactin/growth hormone family are
RT homologous to proteins expressed in the rat.";
RL Endocrinology 138:5541-5549(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=9472921; DOI=10.1095/biolreprod58.1.45;
RA Mueller H., Ishimura R., Orwig K.E., Liu B., Soares M.J.;
RT "Homologues for prolactin-like proteins A and B are present in the mouse.";
RL Biol. Reprod. 58:45-51(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed specifically in placenta. Expressed in
CC both trophoblast giant cells and spongiotrophoblast cells.
CC {ECO:0000269|PubMed:9389542, ECO:0000269|PubMed:9472921}.
CC -!- DEVELOPMENTAL STAGE: Low level on day 8, abundant on days 10 to 14, and
CC decreases by day 16. {ECO:0000269|PubMed:9389542}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF011383; AAB92399.1; -; mRNA.
DR EMBL; AF015562; AAB68824.1; -; mRNA.
DR EMBL; AK141285; BAE24636.1; -; mRNA.
DR EMBL; AK164009; BAE37587.1; -; mRNA.
DR EMBL; AL590616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL606783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052218; AAH52218.1; -; mRNA.
DR CCDS; CCDS26409.1; -.
DR RefSeq; NP_035295.1; NM_011165.3.
DR AlphaFoldDB; O35256; -.
DR SMR; O35256; -.
DR STRING; 10090.ENSMUSP00000021779; -.
DR GlyGen; O35256; 1 site.
DR PaxDb; O35256; -.
DR PRIDE; O35256; -.
DR DNASU; 19110; -.
DR Ensembl; ENSMUST00000021779; ENSMUSP00000021779; ENSMUSG00000005891.
DR GeneID; 19110; -.
DR KEGG; mmu:19110; -.
DR UCSC; uc007pyg.1; mouse.
DR CTD; 19110; -.
DR MGI; MGI:1206587; Prl4a1.
DR VEuPathDB; HostDB:ENSMUSG00000005891; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; O35256; -.
DR OMA; RDTRYFA; -.
DR OrthoDB; 1290070at2759; -.
DR PhylomeDB; O35256; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 19110; 2 hits in 70 CRISPR screens.
DR PRO; PR:O35256; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; O35256; protein.
DR Bgee; ENSMUSG00000005891; Expressed in ectoplacental cone and 18 other tissues.
DR ExpressionAtlas; O35256; baseline and differential.
DR Genevisible; O35256; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; ISS:MGI.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0001666; P:response to hypoxia; IMP:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..227
FT /note="Prolactin-4A1"
FT /id="PRO_0000045168"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 87..203
FT /evidence="ECO:0000250"
FT DISULFID 220..227
FT /evidence="ECO:0000250"
SQ SEQUENCE 227 AA; 26336 MW; 585B2731DCED57B6 CRC64;
MHLSLTPQWS SWTVLLLLVS NLLLWENTAS AMRAKRLNVH DYTTFGNTWN QAIQLSQSMN
HRISELSTHF KVFYAQGRGF EKRTTRCHTS SLSSPENKEQ AQKIQLEVLL GLAHSLLQAW
VNPLYHLWAE MCERLGSTPP ILSKALEVKT LNRNLLETIE KIAFKGNFEI NENGNYTAWS
ELELLQSPNR DTRYFAFHNL FHCLKKDSSH VEMYLKLLKC RLIQSNC
