ID   PR4A1_RAT               Reviewed;         227 AA.
AC   P09320; Q4QR95;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Prolactin-4A1;
DE   AltName: Full=Placental prolactin-like protein A;
DE            Short=PLP-A;
DE            Short=PRL-like protein A;
DE   Flags: Precursor;
GN   Name=Prl4a1; Synonyms=Prlpa;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3755436; DOI=10.1016/s0021-9258(18)67469-1;
RA   Duckworth M.L., Peden L.M., Friesen H.G.;
RT   "Isolation of a novel prolactin-like cDNA clone from developing rat
RT   placenta.";
RL   J. Biol. Chem. 261:10879-10884(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Expressed from days 14 to term of pregnancy.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M13750; AAA41890.1; -; mRNA.
DR   EMBL; BC097332; AAH97332.1; -; mRNA.
DR   PIR; A24911; A24911.
DR   RefSeq; NP_058732.2; NM_017036.2.
DR   AlphaFoldDB; P09320; -.
DR   SMR; P09320; -.
DR   STRING; 10116.ENSRNOP00000022027; -.
DR   GlyGen; P09320; 2 sites.
DR   PaxDb; P09320; -.
DR   PRIDE; P09320; -.
DR   Ensembl; ENSRNOT00000022028; ENSRNOP00000022027; ENSRNOG00000016436.
DR   GeneID; 24656; -.
DR   KEGG; rno:24656; -.
DR   UCSC; RGD:3404; rat.
DR   CTD; 19110; -.
DR   RGD; 3404; Prl4a1.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   GeneTree; ENSGT00950000182818; -.
DR   HOGENOM; CLU_088274_0_1_1; -.
DR   InParanoid; P09320; -.
DR   OMA; RDTRYFA; -.
DR   OrthoDB; 1290070at2759; -.
DR   PhylomeDB; P09320; -.
DR   PRO; PR:P09320; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   ExpressionAtlas; P09320; baseline and differential.
DR   Genevisible; P09320; RN.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..227
FT                   /note="Prolactin-4A1"
FT                   /id="PRO_0000032953"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        87..203
FT                   /evidence="ECO:0000250"
FT   DISULFID        220..227
FT                   /evidence="ECO:0000250"
FT   CONFLICT        172
FT                   /note="E -> Q (in Ref. 1; AAA41890)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   227 AA;  26388 MW;  519F17B0B2DDAD7D CRC64;
     MHLSLSHQWS SWTVLLLLVS NLLLWENTAS AMRAKLLNVH NYTSYGDTWN QAIKISQDMN
     QYISDLSTHV KIFYAQGRGF ERRTTRCHTS SLSSPENKEQ AQQFQLEVLL GLSHSLLQAW
     LNPLHHLWAE MCDRLGSTPP TLYKALMLKE SNIKLLDAIK NIAKKGNFEI NEKANYTAWS
     ELGFLQSPNR DTRYFAFYNL FHCLKKDSNN VEMYLKLLKC RLIRSKC