ID   PR4A_TOBAC              Reviewed;         147 AA.
AC   P29062;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Pathogenesis-related protein PR-4A;
DE   Flags: Precursor;
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Xanthi; TISSUE=Leaf;
RX   PubMed=1745223; DOI=10.1007/bf00290658;
RA   Friedrich L., Moyer M., Ward E., Ryals J.;
RT   "Pathogenesis-related protein 4 is structurally homologous to the carboxy-
RT   terminal domains of hevein, Win-1 and Win-2.";
RL   Mol. Gen. Genet. 230:113-119(1991).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}.
CC   -!- INDUCTION: By TMV infection.
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DR   EMBL; X60281; CAA42820.1; -; mRNA.
DR   PIR; S18598; S18598.
DR   RefSeq; XP_016481278.1; XM_016625792.1.
DR   AlphaFoldDB; P29062; -.
DR   SMR; P29062; -.
DR   GeneID; 107802320; -.
DR   KEGG; nta:107802320; -.
DR   OMA; QGYARGH; -.
DR   OrthoDB; 1414158at2759; -.
DR   PhylomeDB; P29062; -.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR   GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR   Gene3D; 2.40.40.10; -; 1.
DR   InterPro; IPR018226; Barwin_CS.
DR   InterPro; IPR001153; Barwin_dom.
DR   InterPro; IPR044301; PR4.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   PANTHER; PTHR46351; PTHR46351; 1.
DR   Pfam; PF00967; Barwin; 1.
DR   PRINTS; PR00602; BARWIN.
DR   SUPFAM; SSF50685; SSF50685; 1.
DR   PROSITE; PS00771; BARWIN_1; 1.
DR   PROSITE; PS00772; BARWIN_2; 1.
DR   PROSITE; PS51174; BARWIN_3; 1.
PE   2: Evidence at transcript level;
KW   Cell wall; Disulfide bond; Pathogenesis-related protein; Plant defense;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..147
FT                   /note="Pathogenesis-related protein PR-4A"
FT                   /id="PRO_0000002791"
FT   DOMAIN          26..147
FT                   /note="Barwin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00527"
FT   DISULFID        54..86
FT                   /evidence="ECO:0000250"
FT   DISULFID        75..109
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..145
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   147 AA;  16221 MW;  80060A2AFBB40D30 CRC64;
     MERVNNYKLC VALLIISMVM AMAAAQSATN VRSTYHLYNP QNINWDLRAA SAFCATWDAD
     KPLAWRQKYG WTAFCGPAGP RGQDSCGRCL RVTNTGTGTQ TTVRIVDQCS NGGLDLDVNV
     FNQLDTNGVG YQQGHLTVNY EFVNCND