ID   PR5A1_RAT               Reviewed;         227 AA.
AC   Q9JII4; Q9R0R7;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Prolactin-5A1;
DE   AltName: Full=Placental prolactin-like protein L;
DE            Short=PLP-L;
DE            Short=PRL-like protein L;
DE   Flags: Precursor;
GN   Name=Prl5a1; Synonyms=Prlpl;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10471365; DOI=10.1006/bbrc.1999.1260;
RA   Ishibashi K., Imai M.;
RT   "Identification of four members of the rat prolactin/growth hormone gene
RT   family.";
RL   Biochem. Biophys. Res. Commun. 262:575-578(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=10906059; DOI=10.1095/biolreprod63.2.519;
RA   Toft D.J., Linzer D.I.H.;
RT   "Identification of three prolactin-related hormones as markers of invasive
RT   trophoblasts in the rat.";
RL   Biol. Reprod. 63:519-525(2000).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed specifically in placenta. Highly
CC       expressed in invasive trophoblast cells lining the central placental
CC       vessel. {ECO:0000269|PubMed:10906059}.
CC   -!- DEVELOPMENTAL STAGE: Highest levels are observed from day 11 to day 20,
CC       with peak levels on day 13. {ECO:0000269|PubMed:10906059}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA84972.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB022883; BAA84972.1; ALT_FRAME; mRNA.
DR   EMBL; AF226607; AAF89996.1; -; mRNA.
DR   RefSeq; NP_612536.1; NM_138527.1.
DR   AlphaFoldDB; Q9JII4; -.
DR   SMR; Q9JII4; -.
DR   STRING; 10116.ENSRNOP00000021982; -.
DR   GlyGen; Q9JII4; 1 site.
DR   PaxDb; Q9JII4; -.
DR   PRIDE; Q9JII4; -.
DR   Ensembl; ENSRNOT00000117209; ENSRNOP00000086077; ENSRNOG00000016307.
DR   GeneID; 171556; -.
DR   KEGG; rno:171556; -.
DR   UCSC; RGD:620120; rat.
DR   CTD; 28078; -.
DR   RGD; 620120; Prl5a1.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   GeneTree; ENSGT00950000182818; -.
DR   HOGENOM; CLU_088274_0_1_1; -.
DR   InParanoid; Q9JII4; -.
DR   OMA; LLMWENV; -.
DR   OrthoDB; 1290070at2759; -.
DR   PhylomeDB; Q9JII4; -.
DR   TreeFam; TF332592; -.
DR   PRO; PR:Q9JII4; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   ExpressionAtlas; Q9JII4; baseline and differential.
DR   Genevisible; Q9JII4; RN.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..227
FT                   /note="Prolactin-5A1"
FT                   /id="PRO_0000045213"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        85..204
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   227 AA;  26162 MW;  BA50D03193FA2B86 CRC64;
     MQIQPHPSGA LLLLLLSNLL MWENVASVPR CIMENGGCQK VLNYLFNMTS TISESFNTLS
     SETLNDFYTE FDPHQTFQNR PAMTCHTSSR SIPNNKRKAE RMEPAALLNV IIRMLASWKN
     LLYHVENNMA NLDGTPYAII SKVKLIDRQI KKLTKNLQDI KTILSQVHPE LKEKENYPVW
     SGEPYVQKSK RRTQLFGLHS LFFCLYSDAE KVSDYVNILR NKIVPNE