PR6A1_MOUSE
ID PR6A1_MOUSE Reviewed; 230 AA.
AC O35257;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Prolactin-6A1;
DE AltName: Full=Placental prolactin-like protein B;
DE Short=PLP-B;
DE Short=PRL-like protein B;
DE Flags: Precursor;
GN Name=Prl6a1; Synonyms=Prlpb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=9389542; DOI=10.1210/endo.138.12.5626;
RA Lin J., Poole J., Linzer D.I.;
RT "Three new members of the mouse prolactin/growth hormone family are
RT homologous to proteins expressed in the rat.";
RL Endocrinology 138:5541-5549(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=9472921; DOI=10.1095/biolreprod58.1.45;
RA Mueller H., Ishimura R., Orwig K.E., Liu B., Soares M.J.;
RT "Homologues for prolactin-like proteins A and B are present in the mouse.";
RL Biol. Reprod. 58:45-51(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in both placenta and decidual tissues.
CC Detected first in deciduals cells early in gestation and in
CC trophoblasts later in pregnancy. {ECO:0000269|PubMed:9389542,
CC ECO:0000269|PubMed:9472921}.
CC -!- DEVELOPMENTAL STAGE: Increased gradually from days 8-12 and decrease to
CC low levels by days 16. {ECO:0000269|PubMed:9389542,
CC ECO:0000269|PubMed:9472921}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF011384; AAB92400.1; -; mRNA.
DR EMBL; AF015563; AAB68825.1; -; mRNA.
DR EMBL; AL592443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS26395.1; -.
DR RefSeq; NP_035296.1; NM_011166.2.
DR AlphaFoldDB; O35257; -.
DR SMR; O35257; -.
DR STRING; 10090.ENSMUSP00000089269; -.
DR GlyGen; O35257; 1 site.
DR PaxDb; O35257; -.
DR PRIDE; O35257; -.
DR ProteomicsDB; 291810; -.
DR DNASU; 19111; -.
DR Ensembl; ENSMUST00000091680; ENSMUSP00000089269; ENSMUSG00000069259.
DR GeneID; 19111; -.
DR KEGG; mmu:19111; -.
DR UCSC; uc007pxk.2; mouse.
DR CTD; 19111; -.
DR MGI; MGI:1206579; Prl6a1.
DR VEuPathDB; HostDB:ENSMUSG00000069259; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; O35257; -.
DR OMA; YHIANEM; -.
DR OrthoDB; 1290070at2759; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 19111; 2 hits in 71 CRISPR screens.
DR PRO; PR:O35257; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; O35257; protein.
DR Bgee; ENSMUSG00000069259; Expressed in ectoplacental cone and 8 other tissues.
DR ExpressionAtlas; O35257; baseline and differential.
DR Genevisible; O35257; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..230
FT /note="Prolactin-6A1"
FT /id="PRO_0000045210"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 89..205
FT /evidence="ECO:0000250"
FT DISULFID 222..230
FT /evidence="ECO:0000250"
SQ SEQUENCE 230 AA; 26621 MW; 2F0BD63EC7BF0C51 CRC64;
MLSLSQPCFS GTLLMLLASN FLLWKNVAPV PMYASLDEYG EMSIYDLLDH VTILSHNVSE
LTAEMHRIFM EDVRYKPGRW FSDRYLTACH TSTLTISVSK EGARQMPGVF LVKEMISMLT
AWRYPLYHII TELSYMEQAP DEIISRARNI EEKIIVLIEA LRGILSKIQP GPPENERYPV
WNELASLQSP DEDLRHLTLF NLFQCLVKDS RKIDSSIRLL KCKLLYNRDC
