ID   PR6A1_RAT               Reviewed;         234 AA.
AC   P24800; Q63439;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Prolactin-6A1;
DE   AltName: Full=Placental prolactin-like protein B;
DE            Short=PLP-B;
DE            Short=PRL-like protein B;
DE   Flags: Precursor;
GN   Name=Prl6a1; Synonyms=Prlpb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=3185566; DOI=10.1210/mend-2-10-912;
RA   Duckworth M.L., Peden L.M., Friesen H.G.;
RT   "A third prolactin-like protein expressed by the developing rat placenta:
RT   complementary deoxyribonucleic acid sequence and partial structure of the
RT   gene.";
RL   Mol. Endocrinol. 2:912-920(1988).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA41895.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M31155; AAA41891.1; -; mRNA.
DR   EMBL; M31156; AAA41894.1; -; Genomic_DNA.
DR   EMBL; M31156; AAA41895.1; ALT_INIT; Genomic_DNA.
DR   PIR; A40919; A40919.
DR   AlphaFoldDB; P24800; -.
DR   SMR; P24800; -.
DR   STRING; 10116.ENSRNOP00000022944; -.
DR   GlyGen; P24800; 1 site.
DR   PaxDb; P24800; -.
DR   UCSC; RGD:3405; rat.
DR   RGD; 3405; Prl6a1.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   InParanoid; P24800; -.
DR   PhylomeDB; P24800; -.
DR   PRO; PR:P24800; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..234
FT                   /note="Prolactin-6A1"
FT                   /id="PRO_0000032954"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        93..209
FT                   /evidence="ECO:0000250"
FT   DISULFID        226..234
FT                   /evidence="ECO:0000250"
FT   CONFLICT        112
FT                   /note="G -> V (in Ref. 1; AAA41895)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   234 AA;  27148 MW;  3C3496A04C82F9EE CRC64;
     MVKSWLRMSK KMEAGTLLML LMSNILLWEN VASVPRHASG AGRGEMSLHG LLDHAIILAH
     NVTELIAEMN SVFLEDVLYK PGRWFPERDL TACHRSPFTI AVSKEGTQQR LGVFLVKEMI
     GMLETWTFSL YHIANEMSHM EEPPDEIISR AKNIEEKIKE LMDVLKGILN KIQPGSPQNE
     RFPMWNELAY LRSPDEERRH FAFTNLFQCL LQDSRKFDSK VRLLKCRLIY NRDC