PR6AA_XENLA
ID PR6AA_XENLA Reviewed; 423 AA.
AC O42587; Q7SZ30;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=26S proteasome regulatory subunit 6A-A;
DE AltName: Full=26S proteasome AAA-ATPase subunit RPT5-A;
DE AltName: Full=Proteasome 26S subunit ATPase 3-A;
DE AltName: Full=Tat-binding protein 6;
DE Short=TBP-6;
GN Name=psmc3-a {ECO:0000250|UniProtKB:P17980};
GN Synonyms=tbp6 {ECO:0000250|UniProtKB:P17980};
GN ORFNames=XELAEV_18021929mg {ECO:0000312|EMBL:OCT83790.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J {ECO:0000312|Proteomes:UP000186698};
RX PubMed=27762356; DOI=10.1038/nature19840;
RA Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL Nature 538:336-343(2016).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-398.
RC TISSUE=Ovary;
RX PubMed=9375782; DOI=10.1016/s0167-4781(97)00109-7;
RA Nacken W.;
RT "Members of the AAA-gene family are involved in early embryogenesis of
RT vertebrates.";
RL Biochim. Biophys. Acta 1354:1-6(1997).
CC -!- FUNCTION: The 26S proteasome is involved in the ATP-dependent
CC degradation of ubiquitinated proteins. The regulatory (or ATPase)
CC complex confers ATP dependency and substrate specificity to the 26S
CC complex (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: May form a heterodimer with a related family member.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA71487.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA71487.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};
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DR EMBL; BC054164; AAH54164.1; -; mRNA.
DR EMBL; CM004472; OCT83790.1; -; Genomic_DNA.
DR EMBL; Y10461; CAA71487.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001080249.1; NM_001086780.1.
DR AlphaFoldDB; O42587; -.
DR SMR; O42587; -.
DR BioGRID; 98183; 1.
DR STRING; 8355.O42587; -.
DR DNASU; 379941; -.
DR GeneID; 379941; -.
DR CTD; 379941; -.
DR Xenbase; XB-GENE-17333085; psmc3.L.
DR OMA; HEKAAMG; -.
DR OrthoDB; 571919at2759; -.
DR Proteomes; UP000186698; Genome assembly.
DR Bgee; 379941; Expressed in lung and 19 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0036402; F:proteasome-activating activity; IEA:InterPro.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR005937; 26S_Psome_P45-like.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032501; Prot_ATP_ID_OB_C.
DR InterPro; IPR035254; PSMC3.
DR PANTHER; PTHR23073:SF90; PTHR23073:SF90; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF16450; Prot_ATP_ID_OB; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01242; 26Sp45; 1.
DR PROSITE; PS00674; AAA; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Nucleotide-binding; Nucleus; Proteasome;
KW Reference proteome.
FT CHAIN 1..423
FT /note="26S proteasome regulatory subunit 6A-A"
FT /id="PRO_0000084701"
FT BINDING 211..218
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 423 AA; 47397 MW; E95D40E2CD500FF3 CRC64;
MASIWEETEA DGLGEEVLKM STEEIIQRTR LLDSEIKIMK SEVLRVTHEL QAMRDKIKEN
SEKIKVNKTL PYLVSNVIEL LDVDPNDQEE DGANIDLDSQ RKGKCAVIKT STRQTYFLPV
IGLVDAEKLK PGDLVGVNKD SYLILETLPT EYDSRVKAME VDERPTEQYS DIGGLDKQIQ
ELVEAIVLPM NHKEKFENLG IQPPKGVLMY GPPGTGKTLL ARACAAQTKA TFLKLAGPQL
VQMFIGDGAK LVRDAFALAK EKAPSIIFID ELDAIGTKRF DSEKAGDREV QRTMLELLNQ
LDGFQPNMQV KVIAATNRVD ILDPALLRSG RLDRKIEFPM PNEEARARIM QIHSRKMNVS
PDVNYEELAR CTDDFNGAQC KAVCVEAGMI ALRRGATELT HEDYMEGILE VQAKKKANLQ
YYA
