ID   PR73_MMTVC              Reviewed;         319 AA.
AC   P03319; Q9IZS9;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 3.
DT   02-JUN-2021, entry version 63.
DE   RecName: Full=Protein PR73;
DE   AltName: Full=Superantigen;
DE            Short=Sag;
GN   Name=sag;
OS   Mouse mammary tumor virus (strain C3H) (MMTV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Betaretrovirus.
OX   NCBI_TaxID=11759;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6312081; DOI=10.1128/jvi.47.3.495-504.1983;
RA   Majors J.E., Varmus H.E.;
RT   "Nucleotide sequencing of an apparent proviral copy of env mRNA defines
RT   determinants of expression of the mouse mammary tumor virus env gene.";
RL   J. Virol. 47:495-504(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10982330; DOI=10.1128/jvi.74.19.8876-8883.2000;
RA   Hook L.M., Agafonova Y., Ross S.R., Turner S.J., Golovkina T.V.;
RT   "Genetics of mouse mammary tumor virus-induced mammary tumors: linkage of
RT   tumor induction to the gag gene.";
RL   J. Virol. 74:8876-8883(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 122-319.
RX   PubMed=6260976; DOI=10.1128/jvi.37.1.226-238.1981;
RA   Donehower L.A., Huang A.L., Hager G.L.;
RT   "Regulatory and coding potential of the mouse mammary tumor virus long
RT   terminal redundancy.";
RL   J. Virol. 37:226-238(1981).
CC   -!- FUNCTION: Superantigen.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: This protein is coded in the long terminal repeat (LTR).
CC   -!- SIMILARITY: Belongs to the mouse mammary tumor virus PR73 superantigen
CC       family. {ECO:0000305}.
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DR   EMBL; K00556; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AF228552; AAF31476.1; -; Genomic_DNA.
DR   PIR; S26389; QQMVTM.
DR   SMR; P03319; -.
DR   Proteomes; UP000006540; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR001213; MMTV_SAg.
DR   Pfam; PF01054; MMTV_SAg; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal-anchor; Superantigen;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..319
FT                   /note="Protein PR73"
FT                   /id="PRO_0000125501"
FT   TOPO_DOM        1..44
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..319
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        79
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        146
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        38
FT                   /note="V -> M (in Ref. 2; AAF31476)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        59..61
FT                   /note="LGL -> WGP (in Ref. 2; AAF31476)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        207
FT                   /note="P -> L (in Ref. 3; no nucleotide entry)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        310
FT                   /note="A -> P (in Ref. 3; no nucleotide entry)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   319 AA;  36853 MW;  0CE30773DC7329A2 CRC64;
     MPRLQQKWLN SRECPTPRGE AAKGLFPTKD DPSAHKRVSP SDKDIFILCC KLGIALLCLG
     LLGEVAVRAR RALTLDSFNS SSVQDYNLNN SENSTFLLRQ GPQPTSSYKP HRFCPSEIEI
     RMLAKNYIFT NKTNPIGRLL VTMLRNESLS FSTIFTQIQK LEMGIENRKR RSTSIEEQVQ
     GLLTTGLEVK KGKKSVFVKI GDRWWQPGTY RGPYIYRPTD APLPYTGRYD LNWDRWVTVN
     GYKVLYRSLP FRERLARARP PWCMLSQEEK DDMKQQVHDY IYLGTGMHFW GKIFHTKEGT
     VAGLIEHYSA KTYGMSYYE