PR7A1_MOUSE
ID PR7A1_MOUSE Reviewed; 266 AA.
AC O54830; O35334; Q80X21;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Prolactin-7A1;
DE AltName: Full=Placental prolactin-like protein E;
DE Short=PLP-E;
DE Short=PRL-like protein E;
DE AltName: Full=Placental prolactin-like protein G;
DE Short=PLP-G;
DE Short=PRL-like protein G;
DE Flags: Precursor;
GN Name=Prl7a1; Synonyms=Prlpe, Prlpg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J;
RX PubMed=9389541; DOI=10.1210/endo.138.12.5636;
RA Lin J., Poole J., Linzer D.I.;
RT "Two novel members of the prolactin/growth hormone family are expressed in
RT the mouse placenta.";
RL Endocrinology 138:5535-5540(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=9545574; DOI=10.1016/s0167-4781(97)00218-2;
RA Mueller H., Orwig K.E., Soares M.J.;
RT "Identification of two new members of the mouse prolactin gene family.";
RL Biochim. Biophys. Acta 1396:251-258(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O54830-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O54830-2; Sequence=VSP_016678;
CC -!- TISSUE SPECIFICITY: Expressed specifically in the placenta. Detected
CC only in the trophoblast giant cells.
CC -!- DEVELOPMENTAL STAGE: Highest expression at mid-pregnancy.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF011381; AAB92397.1; -; mRNA.
DR EMBL; AF020525; AAB80729.1; -; mRNA.
DR EMBL; AK141309; BAE24644.1; -; mRNA.
DR EMBL; AL590522; CAI23986.1; -; Genomic_DNA.
DR EMBL; AL590522; CAI23985.1; -; Genomic_DNA.
DR EMBL; BC051671; AAH51671.1; -; mRNA.
DR CCDS; CCDS26403.1; -. [O54830-2]
DR CCDS; CCDS49224.1; -. [O54830-1]
DR RefSeq; NP_001157530.1; NM_001164058.1. [O54830-1]
DR RefSeq; NP_032956.1; NM_008930.2. [O54830-2]
DR AlphaFoldDB; O54830; -.
DR SMR; O54830; -.
DR STRING; 10090.ENSMUSP00000093614; -.
DR GlyGen; O54830; 5 sites.
DR PaxDb; O54830; -.
DR PRIDE; O54830; -.
DR DNASU; 19113; -.
DR Ensembl; ENSMUST00000006659; ENSMUSP00000006659; ENSMUSG00000006488. [O54830-2]
DR Ensembl; ENSMUST00000095924; ENSMUSP00000093614; ENSMUSG00000006488. [O54830-1]
DR GeneID; 19113; -.
DR KEGG; mmu:19113; -.
DR UCSC; uc007pxy.2; mouse. [O54830-2]
DR UCSC; uc007pxz.2; mouse. [O54830-1]
DR CTD; 19113; -.
DR MGI; MGI:1206572; Prl7a1.
DR VEuPathDB; HostDB:ENSMUSG00000006488; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; O54830; -.
DR OMA; DICKSPR; -.
DR OrthoDB; 1290070at2759; -.
DR PhylomeDB; O54830; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 19113; 1 hit in 72 CRISPR screens.
DR PRO; PR:O54830; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; O54830; protein.
DR Bgee; ENSMUSG00000006488; Expressed in ectoplacental cone and 11 other tissues.
DR ExpressionAtlas; O54830; baseline and differential.
DR Genevisible; O54830; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..266
FT /note="Prolactin-7A1"
FT /id="PRO_0000045211"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..231
FT /evidence="ECO:0000250"
FT DISULFID 248..257
FT /evidence="ECO:0000250"
FT VAR_SEQ 11..12
FT /note="SG -> W (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:9389541"
FT /id="VSP_016678"
FT CONFLICT 58
FT /note="N -> S (in Ref. 5; AAH51671)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="L -> F (in Ref. 5; AAH51671)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 266 AA; 29828 MW; 293432EBC98F22A6 CRC64;
MPLSFTQPCS SGALLLLVVS NLLLWENVAC LPLSSNDTDD DPLSIKGLLD HAMILSKNIT
DLNMELRRIF TISEMSAKLI DKFLSSSSSS DSYDQFMLEF LGQQELLTKN LTYCHKYSIK
VPEDIEEAQN VISLEDFPIL ILSRMQAWNE TLKNRINLSE GTPGIDDDIL PIYKNIETKI
AELLEDSKSI LSQAYGATEN VADYTLWSGL EDLQSSDEET RFLALCKLSY CLHVDIHTAN
FYLQFLRCVA LVNSDSCLSS KTGNDS
