ID   PR7A2_RAT               Reviewed;         250 AA.
AC   Q9R006;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Prolactin-7A2;
DE   AltName: Full=Placental prolactin-like protein F;
DE            Short=PLP-F;
DE            Short=PRL-like protein F;
DE   Flags: Precursor;
GN   Name=Prl7a2; Synonyms=Prl7a3, Prlpf;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Placenta;
RX   PubMed=10657001; DOI=10.1677/jme.0.0240095;
RA   Sahgal N., Knipp G.T., Liu B., Chapman B.M., Dai G., Soares M.J.;
RT   "Identification of two new nonclassical members of the rat prolactin
RT   family.";
RL   J. Mol. Endocrinol. 24:95-108(2000).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expression restricted to placental tissues.
CC       Trophoblast giant cells are found to be the major source.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF139808; AAD52848.1; -; mRNA.
DR   RefSeq; NP_071975.1; NM_022530.1.
DR   AlphaFoldDB; Q9R006; -.
DR   SMR; Q9R006; -.
DR   STRING; 10116.ENSRNOP00000022381; -.
DR   GlyGen; Q9R006; 4 sites.
DR   PaxDb; Q9R006; -.
DR   GeneID; 64361; -.
DR   KEGG; rno:64361; -.
DR   UCSC; RGD:620035; rat.
DR   CTD; 64361; -.
DR   RGD; 620035; Prl7a3.
DR   InParanoid; Q9R006; -.
DR   OrthoDB; 1290070at2759; -.
DR   PhylomeDB; Q9R006; -.
DR   PRO; PR:Q9R006; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..250
FT                   /note="Prolactin-7A2"
FT                   /id="PRO_0000045131"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        35
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        100..215
FT                   /evidence="ECO:0000250"
FT   DISULFID        232..241
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   250 AA;  28882 MW;  BE55ED3373E53FA9 CRC64;
     MQLSFSRPRP WTLLLMVVSN LLLWENVSSG NLNSNETDGD LLLHRGLFDT ATRLSQDIRD
     LDIEFLRMYA VNEVSEKLYN KHMLEFIEDM DFVVKALTCC HNYSIKTPEN LDEAQQIPFN
     DFPWLILSRM WGWNETSKNL LTILRSIPGM HDDVISLAQA IERKLAELFE YTQSILTLIF
     GPTENVDRSI FSGLEDLKAS DEELRFFALC KFSYCLRVDL QTIELYFKLL QCAVNVNSNV
     CLSINSEDSS