PR7B1_MOUSE
ID PR7B1_MOUSE Reviewed; 251 AA.
AC Q8CGZ9; Q14AN3; Q9DAX1;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Prolactin-7B1;
DE AltName: Full=Placental prolactin-like protein N;
DE Short=PLP-N;
DE Short=PRL-like protein N;
DE Flags: Precursor;
GN Name=Prl7b1; Synonyms=Prlpn;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=CD-1;
RX PubMed=12488360; DOI=10.1210/en.2002-220724;
RA Wiemers D.O., Shao L.-J., Ain R., Dai G., Soares M.J.;
RT "The mouse prolactin gene family locus.";
RL Endocrinology 144:313-325(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expression restricted to placenta. Abundantly
CC expressed in trophoblast cells of the junctional zone and trophoblasts
CC migrating into the mesometrial decidua. {ECO:0000269|PubMed:12488360}.
CC -!- DEVELOPMENTAL STAGE: Detectable throughout the second half of
CC gestation. {ECO:0000269|PubMed:12488360}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF525156; AAN39704.1; -; mRNA.
DR EMBL; AK005458; BAB24049.1; -; mRNA.
DR EMBL; AL590522; CAI23984.1; -; Genomic_DNA.
DR EMBL; BC116772; AAI16773.1; -; mRNA.
DR EMBL; BC119183; AAI19184.1; -; mRNA.
DR CCDS; CCDS26402.1; -.
DR RefSeq; NP_083631.1; NM_029355.2.
DR AlphaFoldDB; Q8CGZ9; -.
DR SMR; Q8CGZ9; -.
DR STRING; 10090.ENSMUSP00000079431; -.
DR GlyGen; Q8CGZ9; 2 sites.
DR PhosphoSitePlus; Q8CGZ9; -.
DR PaxDb; Q8CGZ9; -.
DR PRIDE; Q8CGZ9; -.
DR DNASU; 75596; -.
DR Ensembl; ENSMUST00000080595; ENSMUSP00000079431; ENSMUSG00000021347.
DR GeneID; 75596; -.
DR KEGG; mmu:75596; -.
DR UCSC; uc007pxx.1; mouse.
DR CTD; 75596; -.
DR MGI; MGI:1922846; Prl7b1.
DR VEuPathDB; HostDB:ENSMUSG00000021347; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; Q8CGZ9; -.
DR OMA; NEESRFF; -.
DR OrthoDB; 1290070at2759; -.
DR PhylomeDB; Q8CGZ9; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 75596; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8CGZ9; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8CGZ9; protein.
DR Bgee; ENSMUSG00000021347; Expressed in placenta labyrinth and 13 other tissues.
DR ExpressionAtlas; Q8CGZ9; baseline and differential.
DR Genevisible; Q8CGZ9; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..251
FT /note="Prolactin-7B1"
FT /id="PRO_0000045149"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..216
FT /evidence="ECO:0000250"
FT DISULFID 233..241
FT /evidence="ECO:0000250"
FT CONFLICT 179
FT /note="V -> G (in Ref. 1; AAN39704)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 251 AA; 28960 MW; F946C6018639F221 CRC64;
MNTSLTQLCF WALQILLMSN LLLWEDVVSV PTIGSGSGVS EMLTEDLFDD AIILSQHINS
LAIETRRIFL SNNFSSDMFI TFTLQFNRHD EFVVNGLNSC HTLPLKSPKT EKEAKRISLP
DFMNMILSIL RAWDNPLHHM ETELKSMPGA PFAILARVKD IEVKNKILLD RIMKIAKKVK
YGFEENEVYP AWSELASLQS ANEESRFFAL YKLSYCLFVD TDKVEHYLKH LKCRYFDGYM
CQDSVNQINL L
