ID   PR7B1_RAT               Reviewed;         251 AA.
AC   Q8CJ42;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Prolactin-7B1;
DE   AltName: Full=Placental prolactin-like protein N;
DE            Short=PLP-N;
DE            Short=PRL-like protein N;
DE   Flags: Precursor;
GN   Name=Prl7b1; Synonyms=Prlpn;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=12488360; DOI=10.1210/en.2002-220724;
RA   Wiemers D.O., Shao L.-J., Ain R., Dai G., Soares M.J.;
RT   "The mouse prolactin gene family locus.";
RL   Endocrinology 144:313-325(2003).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF525159; AAN39707.1; -; mRNA.
DR   RefSeq; NP_714960.1; NM_153738.1.
DR   AlphaFoldDB; Q8CJ42; -.
DR   SMR; Q8CJ42; -.
DR   STRING; 10116.ENSRNOP00000022447; -.
DR   GlyGen; Q8CJ42; 1 site.
DR   iPTMnet; Q8CJ42; -.
DR   PhosphoSitePlus; Q8CJ42; -.
DR   PaxDb; Q8CJ42; -.
DR   Ensembl; ENSRNOT00000022447; ENSRNOP00000022447; ENSRNOG00000016742.
DR   GeneID; 266804; -.
DR   KEGG; rno:266804; -.
DR   UCSC; RGD:708582; rat.
DR   CTD; 75596; -.
DR   RGD; 708582; Prl7b1.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   GeneTree; ENSGT00950000182818; -.
DR   HOGENOM; CLU_088274_0_1_1; -.
DR   InParanoid; Q8CJ42; -.
DR   OMA; NEESRFF; -.
DR   OrthoDB; 1290070at2759; -.
DR   PhylomeDB; Q8CJ42; -.
DR   TreeFam; TF332592; -.
DR   PRO; PR:Q8CJ42; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Bgee; ENSRNOG00000016742; Expressed in testis.
DR   ExpressionAtlas; Q8CJ42; baseline and differential.
DR   Genevisible; Q8CJ42; RN.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..251
FT                   /note="Prolactin-7B1"
FT                   /id="PRO_0000045150"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        100..216
FT                   /evidence="ECO:0000250"
FT   DISULFID        233..241
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   251 AA;  29010 MW;  F4B88C33D46A9433 CRC64;
     MHLSLTQQCL WPLQILLVSN LLLWENVAAV PTSDSGLGIS ELLTEDLFDD AVILSQHING
     LAIETRRIFL SNNFSSDMFV KFTLQFNRHD EFVVNGLNSC HTSSLKTPKT EKEAKRISLP
     DFVKMILSIL RAWDSPLYHM ETELKSMTGA PFSILARVKE IEVKNKILLK RIIKIAKKVK
     HGIEENEEYP VWSELASLQS TNEESRFFAL YKMSYCLFVD TDKVEHYLKH LKCRYFDGYM
     CQDPENQISL Q