PR7C1_MOUSE
ID PR7C1_MOUSE Reviewed; 251 AA.
AC Q9CRB5;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Prolactin-7C1;
DE AltName: Full=Placental prolactin-like protein O;
DE Short=PLP-O;
DE Short=PRL-like protein O;
DE Flags: Precursor;
GN Name=Prl7c1; Synonyms=Prlpo;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=CD-1;
RX PubMed=12488360; DOI=10.1210/en.2002-220724;
RA Wiemers D.O., Shao L.-J., Ain R., Dai G., Soares M.J.;
RT "The mouse prolactin gene family locus.";
RL Endocrinology 144:313-325(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Extraembryonic tissue, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in the placenta. Expressed in
CC spongiotrophoblast cells and trophoblast giant cells of the junctional
CC zone and in labyrinthine trophoblast. {ECO:0000269|PubMed:12488360}.
CC -!- DEVELOPMENTAL STAGE: Detectable throughout the second half of
CC gestation. {ECO:0000269|PubMed:12488360}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF525157; AAN39705.1; -; mRNA.
DR EMBL; AK005486; BAB24072.1; -; mRNA.
DR EMBL; AK014436; BAB29348.1; -; mRNA.
DR EMBL; AL627326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC099442; AAH99442.1; -; mRNA.
DR CCDS; CCDS26406.1; -.
DR RefSeq; NP_080482.1; NM_026206.2.
DR AlphaFoldDB; Q9CRB5; -.
DR SMR; Q9CRB5; -.
DR STRING; 10090.ENSMUSP00000072712; -.
DR GlyGen; Q9CRB5; 1 site.
DR iPTMnet; Q9CRB5; -.
DR PhosphoSitePlus; Q9CRB5; -.
DR PaxDb; Q9CRB5; -.
DR PRIDE; Q9CRB5; -.
DR DNASU; 67505; -.
DR Ensembl; ENSMUST00000072943; ENSMUSP00000072712; ENSMUSG00000060738.
DR GeneID; 67505; -.
DR KEGG; mmu:67505; -.
DR UCSC; uc007pyd.1; mouse.
DR CTD; 67505; -.
DR MGI; MGI:1914755; Prl7c1.
DR VEuPathDB; HostDB:ENSMUSG00000060738; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; Q9CRB5; -.
DR OMA; LYKLFYC; -.
DR OrthoDB; 1290070at2759; -.
DR PhylomeDB; Q9CRB5; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 67505; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q9CRB5; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9CRB5; protein.
DR Bgee; ENSMUSG00000060738; Expressed in ectoplacental cone and 1 other tissue.
DR ExpressionAtlas; Q9CRB5; baseline and differential.
DR Genevisible; Q9CRB5; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..251
FT /note="Prolactin-7C1"
FT /id="PRO_0000045151"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..217
FT /evidence="ECO:0000250"
FT DISULFID 234..242
FT /evidence="ECO:0000250"
SQ SEQUENCE 251 AA; 29258 MW; 05D94595E82DEEE6 CRC64;
MLLSLTHPSF LAMLPMLLMS NLLQWEGVTS ASIHHIEDDY GEAYLKDLFD QAIKLSNDTM
ALTIEMRMIF FSDGFSSNMF RKIVLDFLKD HKHMIETLNS CHTFSLSVPE TLEEARKISL
EDFLKIIVSI LNSWNKPLYH LETELHCMKG APDAILIRAN AIRTLNRELL ETILMILSRV
HPGMEENTDY PLWTDLASLQ ATNKERQFFA LYKLFYCLRV DTFTVDHYLK YLMCMLYSDD
ICTSVKFYED P
