PR7D1_MOUSE
ID PR7D1_MOUSE Reviewed; 244 AA.
AC P04769;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Prolactin-7D1;
DE AltName: Full=Proliferin-related protein;
DE Short=PRP;
DE Flags: Precursor;
GN Name=Prl7d1; Synonyms=Plfr;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=4029117; DOI=10.1002/j.1460-2075.1985.tb03796.x;
RA Linzer D.I.H., Nathans D.;
RT "A new member of the prolactin-growth hormone gene family expressed in
RT mouse placenta.";
RL EMBO J. 4:1419-1423(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- DEVELOPMENTAL STAGE: PRP mRNA levels are highest in the fetal part of
CC the placenta and peak at day 12 of gestation, decreasing gradually
CC until term.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; X02594; CAA26437.1; -; mRNA.
DR EMBL; AK019461; BAB31733.1; -; mRNA.
DR EMBL; AK030276; BAC26872.1; -; mRNA.
DR CCDS; CCDS26405.1; -.
DR RefSeq; NP_035250.1; NM_011120.2.
DR AlphaFoldDB; P04769; -.
DR SMR; P04769; -.
DR STRING; 10090.ENSMUSP00000021776; -.
DR PaxDb; P04769; -.
DR PRIDE; P04769; -.
DR DNASU; 18814; -.
DR Ensembl; ENSMUST00000224026; ENSMUSP00000153033; ENSMUSG00000021348.
DR GeneID; 18814; -.
DR KEGG; mmu:18814; -.
DR UCSC; uc007pyb.2; mouse.
DR CTD; 18814; -.
DR MGI; MGI:97619; Prl7d1.
DR VEuPathDB; HostDB:ENSMUSG00000021348; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; P04769; -.
DR OMA; SALMCKA; -.
DR OrthoDB; 1290070at2759; -.
DR PhylomeDB; P04769; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 18814; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Prl7d1; mouse.
DR PRO; PR:P04769; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; P04769; protein.
DR Bgee; ENSMUSG00000021348; Expressed in placenta labyrinth and 34 other tissues.
DR ExpressionAtlas; P04769; baseline and differential.
DR Genevisible; P04769; MM.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR GO; GO:0005179; F:hormone activity; IDA:MGI.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0043534; P:blood vessel endothelial cell migration; IDA:MGI.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IDA:MGI.
DR GO; GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:MGI.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0060674; P:placenta blood vessel development; IMP:MGI.
DR GO; GO:0001890; P:placenta development; IMP:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..244
FT /note="Prolactin-7D1"
FT /id="PRO_0000032970"
FT DISULFID 99..215
FT /evidence="ECO:0000250"
FT DISULFID 232..240
FT /evidence="ECO:0000250"
SQ SEQUENCE 244 AA; 27952 MW; ACFE08C9AACAEC02 CRC64;
MLPSLIQPCS SGTLLMLLMS NLFLWEKVSS APINASEAVL SDLKDLFDNA TVLSGEMSKL
GVIMRKEFFM NSFSSETFNK IILDLHKSTE NITKAFNSCH TVPINVPETV EDVRKTSFEE
FLKMVLHMLL AWKEPLKHLV TELSALPECP YRILSKAEAI EAKNKDLLEY IIRIISKVNP
AIKENEDYPT WSDLDSLKSA DKETQFFALY MFSFCLRIDL ETVDFLVNFL KCLLLYDDVC
YSEF
