ID   PR8A4_RAT               Reviewed;         239 AA.
AC   P33580; Q9R2D1;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Prolactin-8A4;
DE   AltName: Full=Growth hormone-related placental protein 3;
DE   AltName: Full=Placental prolactin-like protein H;
DE            Short=PLP-H;
DE            Short=PRL-like protein H;
DE   Flags: Precursor;
GN   Name=Prl8a4; Synonyms=Prlph;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=9832436; DOI=10.1210/endo.139.12.6373;
RA   Iwatsuki K., Oda M., Sun W., Tanaka S., Ogawa T., Shiota K.;
RT   "Molecular cloning and characterization of a new member of the rat
RT   placental prolactin (PRL) family, PRL-like protein H.";
RL   Endocrinology 139:4976-4983(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 32-68.
RC   TISSUE=Placenta;
RX   PubMed=2351117; DOI=10.1210/endo-126-6-3271;
RA   Ogilvie S., Buhi W.C., Olson J.A., Shiverick K.T.;
RT   "Identification of a novel family of growth hormone-related proteins
RT   secreted by rat placenta.";
RL   Endocrinology 126:3271-3273(1990).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Placental basal zone cells.
CC       {ECO:0000269|PubMed:9832436}.
CC   -!- DEVELOPMENTAL STAGE: Mid to late gestation (gestation day 15).
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AB009889; BAA32480.1; -; mRNA.
DR   PIR; C60580; C60580.
DR   RefSeq; NP_067591.1; NM_021580.1.
DR   AlphaFoldDB; P33580; -.
DR   SMR; P33580; -.
DR   GlyGen; P33580; 2 sites.
DR   PaxDb; P33580; -.
DR   GeneID; 59088; -.
DR   KEGG; rno:59088; -.
DR   UCSC; RGD:620116; rat.
DR   CTD; 59088; -.
DR   RGD; 620116; Prl8a4.
DR   InParanoid; P33580; -.
DR   OrthoDB; 1359874at2759; -.
DR   PhylomeDB; P33580; -.
DR   PRO; PR:P33580; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..239
FT                   /note="Prolactin-8A4"
FT                   /id="PRO_0000043398"
FT   CARBOHYD        211
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        218
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        35..42
FT                   /evidence="ECO:0000255"
FT   DISULFID        102..215
FT                   /evidence="ECO:0000250"
FT   DISULFID        232..239
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   239 AA;  27407 MW;  BC55CB1F73635134 CRC64;
     MMKLALSQPP FSGTLLMLVV SILLLWEKAA SIPACMVEEG DCWDPLQETF NSAIQRAETL
     CNLADQLYVE FYQNQFSSRQ FADLNSKLIK RDETVLKAGI YCHSTLAKPQ TRGGNFEIEE
     HLKMLINFVG SWISPLFHLV IELSAMEGVP ETILCKVKDL EENNRQLLDD LRWILTKVSP
     TAEIREEFPS WEHLSFLKSS NKNNKFLAMF NLSNCLDNDT KFTLHHLRIF KCLITGKDC