PR8A5_RAT
ID PR8A5_RAT Reviewed; 238 AA.
AC P33579;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Prolactin-8A5;
DE AltName: Full=Growth hormone-related placental protein 2;
DE AltName: Full=Placental prolactin-like protein C;
DE Short=PLP-C;
DE Short=PRL-like protein C;
DE Flags: Precursor;
GN Name=Prl8a5; Synonyms=Prlpc;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1744098; DOI=10.1016/s0021-9258(18)54458-6;
RA Deb S., Roby K.F., Faria T.N., Szpirer C., Levan G., Kwok S.C.M.,
RA Soares M.J.;
RT "Molecular cloning and characterization of prolactin-like protein C
RT complementary deoxyribonucleic acid.";
RL J. Biol. Chem. 266:23027-23032(1991).
RN [2]
RP PROTEIN SEQUENCE OF 31-67.
RC TISSUE=Placenta;
RX PubMed=2351117; DOI=10.1210/endo-126-6-3271;
RA Ogilvie S., Buhi W.C., Olson J.A., Shiverick K.T.;
RT "Identification of a novel family of growth hormone-related proteins
RT secreted by rat placenta.";
RL Endocrinology 126:3271-3273(1990).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Placental basal zone cells.
CC -!- DEVELOPMENTAL STAGE: Mid to late gestation (gestation day 15).
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; M76537; AAA41945.1; -; mRNA.
DR PIR; A41568; A41568.
DR AlphaFoldDB; P33579; -.
DR SMR; P33579; -.
DR STRING; 10116.ENSRNOP00000022658; -.
DR GlyGen; P33579; 2 sites.
DR UCSC; RGD:708348; rat.
DR RGD; 708348; Prl8a5.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR InParanoid; P33579; -.
DR PhylomeDB; P33579; -.
DR PRO; PR:P33579; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IEP:RGD.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000269|PubMed:2351117"
FT CHAIN 31..238
FT /note="Prolactin-8A5"
FT /id="PRO_0000032955"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 34..41
FT /evidence="ECO:0000255"
FT DISULFID 101..214
FT /evidence="ECO:0000250"
FT DISULFID 231..238
FT /evidence="ECO:0000250"
SQ SEQUENCE 238 AA; 27246 MW; 4E89E9ED663A9746 CRC64;
MELALSQPSF FGTLLMLVVS NLLLWEKAAS IPACMVEDGG CWDPLREAFN SATQRAETLR
NLSDQLYVEF FQNQFSSRQF ADLSSQLIRK DETVLKAGTY CHSNRAKPKS RGVNIDIEEY
LKMSINFCGF MDQPLFHLVI ELSAMEGVPE TILSKAKDLE ENNRQLLDDL RWILTKVFPT
AEIKEEFPSW DYLSFLKSSN KNHKFLAIFN LSSCLDYDTQ VHYTLSQILN CLITGKDC
