PR8A6_MOUSE
ID PR8A6_MOUSE Reviewed; 240 AA.
AC Q9DAY2; Q9DAW0; Q9Z249;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Prolactin-8A6;
DE AltName: Full=Placental prolactin-like protein C1;
DE Short=PLP-C1;
DE Short=PRL-like protein C1;
DE AltName: Full=Prolactin-like protein C-alpha;
DE Short=PLP C-alpha;
DE Short=Prolactin-like protein C;
DE Flags: Precursor;
GN Name=Prl8a6; Synonyms=Prlpc, Prlpc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=CD-1;
RX PubMed=9832456; DOI=10.1210/endo.139.12.6391;
RA Dai G., Chapman B.M., Liu B., Orwig K.E., Wang D., White R.A., Preuett B.,
RA Soares M.J.;
RT "A new member of the mouse prolactin (PRL)-like protein-C subfamily, PRL-
RT like protein-C alpha: structure and expression.";
RL Endocrinology 139:5157-5163(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9DAY2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DAY2-2; Sequence=VSP_016904;
CC Name=3;
CC IsoId=Q9DAY2-3; Sequence=VSP_016903;
CC -!- TISSUE SPECIFICITY: Expressed specifically in the spongiotrophoblast
CC and trophoblast giant cells from the junctional zone of the
CC chorioallantoic placenta. {ECO:0000269|PubMed:9832456}.
CC -!- DEVELOPMENTAL STAGE: Expression increased from midgestation to the end
CC of the pregnancy. {ECO:0000269|PubMed:9832456}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF090140; AAD09012.1; -; mRNA.
DR EMBL; AK005435; BAB24029.1; -; mRNA.
DR EMBL; AK005478; BAB24067.1; -; mRNA.
DR EMBL; AL592443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC099469; AAH99469.1; -; mRNA.
DR CCDS; CCDS26398.1; -. [Q9DAY2-3]
DR CCDS; CCDS70441.1; -. [Q9DAY2-2]
DR CCDS; CCDS70442.1; -. [Q9DAY2-1]
DR RefSeq; NP_001258307.1; NM_001271378.1. [Q9DAY2-1]
DR RefSeq; NP_001258308.1; NM_001271379.1. [Q9DAY2-2]
DR RefSeq; NP_035297.1; NM_011167.3. [Q9DAY2-3]
DR AlphaFoldDB; Q9DAY2; -.
DR SMR; Q9DAY2; -.
DR STRING; 10090.ENSMUSP00000105984; -.
DR GlyGen; Q9DAY2; 1 site.
DR PaxDb; Q9DAY2; -.
DR PeptideAtlas; Q9DAY2; -.
DR PRIDE; Q9DAY2; -.
DR ProteomicsDB; 289829; -. [Q9DAY2-1]
DR ProteomicsDB; 289830; -. [Q9DAY2-2]
DR ProteomicsDB; 289831; -. [Q9DAY2-3]
DR DNASU; 19112; -.
DR Ensembl; ENSMUST00000018392; ENSMUSP00000018392; ENSMUSG00000021345. [Q9DAY2-3]
DR Ensembl; ENSMUST00000080762; ENSMUSP00000079584; ENSMUSG00000021345. [Q9DAY2-2]
DR Ensembl; ENSMUST00000110355; ENSMUSP00000105984; ENSMUSG00000021345. [Q9DAY2-1]
DR GeneID; 19112; -.
DR KEGG; mmu:19112; -.
DR UCSC; uc007pxo.2; mouse. [Q9DAY2-3]
DR UCSC; uc007pxp.2; mouse. [Q9DAY2-1]
DR UCSC; uc007pxq.2; mouse. [Q9DAY2-2]
DR CTD; 19112; -.
DR MGI; MGI:1332225; Prl8a6.
DR VEuPathDB; HostDB:ENSMUSG00000021345; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; Q9DAY2; -.
DR OMA; PNKENEH; -.
DR PhylomeDB; Q9DAY2; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 19112; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Prl8a6; mouse.
DR PRO; PR:Q9DAY2; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9DAY2; protein.
DR Bgee; ENSMUSG00000021345; Expressed in placenta labyrinth and 7 other tissues.
DR ExpressionAtlas; Q9DAY2; baseline and differential.
DR Genevisible; Q9DAY2; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; ISA:MGI.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..240
FT /note="Prolactin-8A6"
FT /id="PRO_0000045396"
FT CARBOHYD 212
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 34..41
FT /evidence="ECO:0000255"
FT DISULFID 101..216
FT /evidence="ECO:0000250"
FT DISULFID 233..240
FT /evidence="ECO:0000250"
FT VAR_SEQ 11..12
FT /note="SG -> C (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:9832456"
FT /id="VSP_016903"
FT VAR_SEQ 84..118
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_016904"
SQ SEQUENCE 240 AA; 27274 MW; F66C404BA4760EC8 CRC64;
MALLLSQPHF SGPLLLLVVS NLLLWEKAAS NLPCVAEEGG CWNPLLETFN SATQKAETLH
NLADQLYVEL YYNQFSSGQF WDFSSQIIRQ DKTVVRAGSY CHSSLTNPPN TGVHINIEIA
SYLKTLINFV GSWISPLFHL VIELSATKDV PETILSKAKE IEENNRQILS DLRWILTKVS
PAAEMTEEFP HWEYLSFLKS SDKNNKFLAM FNLSYCIDHD SKYILLQLRL LKCLITGKDC
