ID   PR8A7_RAT               Reviewed;         240 AA.
AC   P33578; P97786; Q4FZY5;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Prolactin-8A7;
DE   AltName: Full=Growth hormone-related protein 1;
DE   AltName: Full=Placental prolactin-like protein D;
DE            Short=PLP-D;
DE            Short=PRL-like protein D;
DE   Flags: Precursor;
GN   Name=Prl8a7; Synonyms=Prlpd;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Placenta;
RX   PubMed=8756556; DOI=10.1210/endo.137.9.8756556;
RA   Iwatsuki K., Shinozaki M., Hattori N., Hirasawa K., Itagaki S., Shiota K.,
RA   Ogawa T.;
RT   "Molecular cloning and characterization of a new member of the rat
RT   placental prolactin (PRL) family, PRL-like protein D (PLP-D).";
RL   Endocrinology 137:3849-3855(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 30-74.
RC   TISSUE=Placenta;
RX   PubMed=2351117; DOI=10.1210/endo-126-6-3271;
RA   Ogilvie S., Buhi W.C., Olson J.A., Shiverick K.T.;
RT   "Identification of a novel family of growth hormone-related proteins
RT   secreted by rat placenta.";
RL   Endocrinology 126:3271-3273(1990).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Placental basal zone cells.
CC   -!- DEVELOPMENTAL STAGE: Mid to late gestation (gestation day 15).
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AB000107; BAA19054.1; -; mRNA.
DR   EMBL; BC098917; AAH98917.1; -; mRNA.
DR   PIR; A60580; A60580.
DR   RefSeq; NP_071982.1; NM_022537.1.
DR   RefSeq; XP_006253971.1; XM_006253909.1.
DR   AlphaFoldDB; P33578; -.
DR   SMR; P33578; -.
DR   STRING; 10116.ENSRNOP00000022797; -.
DR   GlyGen; P33578; 1 site.
DR   PaxDb; P33578; -.
DR   GeneID; 64368; -.
DR   KEGG; rno:64368; -.
DR   UCSC; RGD:620115; rat.
DR   CTD; 64368; -.
DR   RGD; 620115; Prl8a7.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   InParanoid; P33578; -.
DR   OrthoDB; 1359874at2759; -.
DR   PhylomeDB; P33578; -.
DR   PRO; PR:P33578; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..240
FT                   /note="Prolactin-8A7"
FT                   /id="PRO_0000043397"
FT   CARBOHYD        212
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        33..40
FT                   /evidence="ECO:0000255"
FT   DISULFID        100..216
FT                   /evidence="ECO:0000250"
FT   DISULFID        233..240
FT                   /evidence="ECO:0000250"
FT   CONFLICT        66
FT                   /note="H -> W (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   240 AA;  27270 MW;  EB672DF8F793EEAC CRC64;
     MELPLSQHSF CKLLLLVVSS LLLWEKAASI PACLAEEGGC WNPLVETFNS AIHKAETLYD
     LANQIHVELY QNKFSSEQFS SLNSQVIRKD KTALRAGSYC HSTLINTPNK ENEHINIEIK
     EYVKTLINFV GAWISPLYHL VLELSAMQDV PESILSKAKE IEENNRQLLD DLKWILIKVS
     PTEEMKEEFP SWGHLSFLKS SGEKSKFLAM FNLSNCLGYD AKYTLLNLRI LKCLTTGKDC