PR8A8_MOUSE
ID PR8A8_MOUSE Reviewed; 241 AA.
AC Q9DAS4; Q8VHE8;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Prolactin-8A8;
DE AltName: Full=Placental prolactin-like protein C3;
DE Short=PLP-C3;
DE Short=PRL-like protein C3;
DE AltName: Full=Prolactin-like protein C-gamma;
DE Short=PLP C-gamma;
DE Flags: Precursor;
GN Name=Prl8a8; Synonyms=Prlpc3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY (ISOFORM 2).
RC STRAIN=CD-1; TISSUE=Placenta;
RX PubMed=12488360; DOI=10.1210/en.2002-220724;
RA Wiemers D.O., Shao L.-J., Ain R., Dai G., Soares M.J.;
RT "The mouse prolactin gene family locus.";
RL Endocrinology 144:313-325(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=ICR; TISSUE=Placenta;
RA Hwang I.-T., Lee Y.-H., Chun J.-Y.;
RT "Molecular cloning and characterization of a newly identified member of the
RT mouse placental prolactin-like protein C subfamily.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9DAS4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DAS4-2; Sequence=VSP_016781;
CC -!- TISSUE SPECIFICITY: Expressed specifically in the placenta.
CC Predominantly expressed in spongiotrophoblast cells.
CC -!- DEVELOPMENTAL STAGE: Increases in abundance as gestation advanced.
CC Predominandtly expressed in the junctional zone during the latter third
CC of gestation.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF466150; AAL73987.1; -; mRNA.
DR EMBL; AF230921; AAN76491.1; -; mRNA.
DR EMBL; AF230922; AAN76492.1; -; mRNA.
DR EMBL; AK005568; BAB24128.1; -; mRNA.
DR EMBL; AK167369; BAE39465.1; -; mRNA.
DR EMBL; AL590522; CAI23980.1; -; Genomic_DNA.
DR EMBL; BC100326; AAI00327.1; -; mRNA.
DR CCDS; CCDS26399.1; -. [Q9DAS4-2]
DR CCDS; CCDS79173.1; -. [Q9DAS4-1]
DR RefSeq; NP_001298054.1; NM_001311125.1. [Q9DAS4-1]
DR RefSeq; NP_076230.1; NM_023741.2. [Q9DAS4-2]
DR AlphaFoldDB; Q9DAS4; -.
DR SMR; Q9DAS4; -.
DR STRING; 10090.ENSMUSP00000105979; -.
DR GlyGen; Q9DAS4; 1 site.
DR PaxDb; Q9DAS4; -.
DR PRIDE; Q9DAS4; -.
DR TopDownProteomics; Q9DAS4-1; -. [Q9DAS4-1]
DR DNASU; 74188; -.
DR Ensembl; ENSMUST00000018389; ENSMUSP00000018389; ENSMUSG00000021346. [Q9DAS4-2]
DR Ensembl; ENSMUST00000110350; ENSMUSP00000105979; ENSMUSG00000021346. [Q9DAS4-1]
DR GeneID; 74188; -.
DR KEGG; mmu:74188; -.
DR UCSC; uc007pxr.1; mouse. [Q9DAS4-2]
DR UCSC; uc007pxt.1; mouse. [Q9DAS4-1]
DR CTD; 74188; -.
DR MGI; MGI:1921438; Prl8a8.
DR VEuPathDB; HostDB:ENSMUSG00000021346; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_0_1; -.
DR OMA; TIHYLKI; -.
DR PhylomeDB; Q9DAS4; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 74188; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Prl8a8; mouse.
DR PRO; PR:Q9DAS4; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9DAS4; protein.
DR Bgee; ENSMUSG00000021346; Expressed in placenta labyrinth and 9 other tissues.
DR ExpressionAtlas; Q9DAS4; baseline and differential.
DR Genevisible; Q9DAS4; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..241
FT /note="Prolactin-8A8"
FT /id="PRO_0000045332"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 34..41
FT /evidence="ECO:0000255"
FT DISULFID 101..217
FT /evidence="ECO:0000250"
FT DISULFID 234..241
FT /evidence="ECO:0000250"
FT VAR_SEQ 11..12
FT /note="SD -> Y (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_016781"
SQ SEQUENCE 241 AA; 28089 MW; 455BB3BE418801FA CRC64;
MELQFRQPHF SDALLLLLLS NLLLWEKASS IPACMAEKSG CWNPRMETFD SAIRKAETLR
TVSKQFYVEL YHNQFSSGKF ATLTSKLVRR DEIVFRAASH CHSTLTNPPN KGIQYITIEI
PEYLKTLINY VGAWISPLFH LVIELSAMKD VPETILSKAK EIEENNRQIL RDLRWIITEV
YPTSKKKEIF PSWELLSFLK SSSRNSKFLA MFNLSHCLEY DTQFFLFHLR ILKCRITGKD
C
