PR8A9_MOUSE
ID PR8A9_MOUSE Reviewed; 241 AA.
AC Q9CQ58;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Prolactin-8A9;
DE AltName: Full=Placental prolactin-like protein C2;
DE Short=PLP-C2;
DE Short=PRL-like protein C2;
DE AltName: Full=Prolactin-like protein C-beta;
DE Short=PLP C-beta;
DE Flags: Precursor;
GN Name=Prl8a9; Synonyms=Prlpc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=ICR;
RX PubMed=10965907; DOI=10.1210/endo.141.9.7635;
RA Hwang I.-T., Lee Y.-H., Moon B.-C., Ahn K.-Y., Lee S.-W., Chun J.-Y.;
RT "Identification and characterization of a new member of the placental
RT prolactin-like protein-C (PLP-C) subfamily, PLP-Cbeta.";
RL Endocrinology 141:3343-3352(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Detected only in placenta. Localized to
CC spongiotrophoblasts and trophoblast giant cells of the placenta.
CC {ECO:0000269|PubMed:10965907}.
CC -!- DEVELOPMENTAL STAGE: First detected at 11.5 dpc and expressed
CC continually throughout development, its expression level fluctuated
CC during gestation. {ECO:0000269|PubMed:10965907}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF158744; AAK81734.1; -; mRNA.
DR EMBL; AK005409; BAB24008.1; -; mRNA.
DR EMBL; AK005494; BAB24079.1; -; mRNA.
DR EMBL; AL590522; CAI23981.1; -; Genomic_DNA.
DR EMBL; BC064762; AAH64762.1; -; mRNA.
DR CCDS; CCDS26400.1; -.
DR RefSeq; NP_001303650.1; NM_001316721.1.
DR RefSeq; NP_075821.1; NM_023332.4.
DR AlphaFoldDB; Q9CQ58; -.
DR SMR; Q9CQ58; -.
DR STRING; 10090.ENSMUSP00000006662; -.
DR GlyGen; Q9CQ58; 2 sites.
DR iPTMnet; Q9CQ58; -.
DR PhosphoSitePlus; Q9CQ58; -.
DR PaxDb; Q9CQ58; -.
DR PeptideAtlas; Q9CQ58; -.
DR PRIDE; Q9CQ58; -.
DR ProteomicsDB; 289832; -.
DR DNASU; 67310; -.
DR Ensembl; ENSMUST00000006662; ENSMUSP00000006662; ENSMUSG00000006490.
DR GeneID; 67310; -.
DR KEGG; mmu:67310; -.
DR UCSC; uc007pxu.1; mouse.
DR CTD; 67310; -.
DR MGI; MGI:1914560; Prl8a9.
DR VEuPathDB; HostDB:ENSMUSG00000006490; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR InParanoid; Q9CQ58; -.
DR OMA; TFNSAMQ; -.
DR OrthoDB; 1359874at2759; -.
DR PhylomeDB; Q9CQ58; -.
DR TreeFam; TF332592; -.
DR BioGRID-ORCS; 67310; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Prl8a9; mouse.
DR PRO; PR:Q9CQ58; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9CQ58; protein.
DR Bgee; ENSMUSG00000006490; Expressed in placenta labyrinth and 17 other tissues.
DR ExpressionAtlas; Q9CQ58; baseline and differential.
DR Genevisible; Q9CQ58; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..241
FT /note="Prolactin-8A9"
FT /id="PRO_0000045327"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 220
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 34..41
FT /evidence="ECO:0000255"
FT DISULFID 101..217
FT /evidence="ECO:0000250"
FT DISULFID 234..241
FT /evidence="ECO:0000250"
SQ SEQUENCE 241 AA; 27697 MW; C1DD70537742F3AF CRC64;
MVLPLSQPHF SGALLLLVVS NLLLWEKASA IPACMAQKSG CWNPLVETFN SAMQTAGTLR
TLADQFYVEL YHNQFSSGQF LIFNSNLIRR DETVARAGTY CHSTLSNPPD RGTEHADAET
EKYLKTLINY VGAWIGPLYH VVIELNVMQD VPETILSKVR QIEENKRKLL EDLRWILTKV
YPTAEMKEEF PAWEHLSFLK SQGKHYKLLA MFNLSNCIYN ETYHILFYLR ELKCQITGED
C
